术前外周血PLR与局部晚期宫颈癌患者临床病理特征及预后的关系  

Correlation between preoperative peripheral blood PLR andclinicopathological features and prognosis of patients with locally advanced cervical cancer

作　　者：邵佳[1] 张璨 何爱琴[1] 陈蕾[1] SHAO Jia;ZHANG Can;HE Aiqin;CHEN Lei(Department of Gynecology,Affiliated Tumor Hospital of Nantong University/Nanjing Tumor Hospital,Nantong 226361,China)

机构地区：[1]南通大学附属肿瘤医院肿瘤/南通市肿瘤医院肿瘤妇科,江苏南通226361

出　　处：《中国肿瘤外科杂志》2022年第5期479-483,共5页Chinese Journal of Surgical Oncology

基　　金：南通市科技计划项目(JC22022107);南通市卫生健康委员会科研立项课题(QA2019027)。

摘　　要：目的探讨局部晚期宫颈癌患者术前外周血血小板与淋巴细胞比值(PLR),与其临床病理特征及预后的关系。方法回顾性分析2015年1月至2018年12月在南通大学附属肿瘤医院接受宫颈癌根治术的81例局部晚期宫颈癌患者临床病理资料。将ROC曲线约登指数最大值所对应的PLR值确定为截断值,并以此为标准将患者分为低PLR组与高PLR组,分析术前外周血PLR水平与其临床病理特征及预后的关系。结果PLR截断值为149.01。两组患者在国际妇产科联盟(FIGO)分期、组织分级、淋巴结转移方面差异有统计学意义(P<0.05),高PLR组具有淋巴结转移率高、FIGO分期晚及组织分化级别高的特点。单因素分析显示,组织分级、淋巴结是否转移、术前PLR水平与总生存期(OS)有关(P<0.05),进一步Cox多因素分析显示,淋巴结转移及PLR≥149.01是影响局部晚期宫颈癌患者OS的独立危险因素(P<0.05)。Kaplan-Meier生存分析显示,低PLR组患者的OS明显高于高PLR组患者,差异有统计学意义(P=0.002)。结论术前外周血PLR水平是局部晚期宫颈癌患者的独立预后因素,高PLR患者预后较差。Objective To investigate the correlation between preoperative peripheral blood platelet to lymphocyte ratio(PLR)and clinicopathological features and prognosis in patients with locally advanced cervical cancer.Methods The clinicopathological data of 81 patients with locally advanced cervical cancer who underwent radical surgery in the Affiliated Cancer Hospital of Nantong University from January 2015 to December 2018 were analyzed retrospectively.The cutoff value of PLR was determined by ROC curve which was used to be the reference to divided the patients into low PLR group and high PLR group.The correlation between preoperative peripheral blood PLR level and its clinicopathological features and prognosis was analyzed.Results The cut-off value of PLR was 149.01.There were significant differences in FIGO stage,tissue grade and the incidence of lymph node metastasis between the two groups(P<0.05).The patients in high PLR group were characterized by high lymph node metastasis rate,late stage of FIGO and high level of tissue differentiation.Univariate analysis showed that tissue grade,lymph node metastasis and preoperative PLR level were related to OS(P<0.05).Cox multivariate analysis showed that lymph node metastasis and PLR≥149.01 were independent risk factors for OS in patients with locally advanced cervical cancer(P<0.05).Kaplan-Meier survival analysis showed that the OS of patients in low PLR group was significantly longer than that in high PLR group(P=0.002).Conclusions Preoperative peripheral blood PLR level is an independent prognostic factor for patients with locally advanced cervical cancer.And the prognosis of patients with high PLR is poor.

关 键 词：局部晚期 宫颈癌 血小板与淋巴细胞比值 预后 

分 类 号：R737.33[医药卫生—肿瘤]