静脉注射联合口服给药方案的建模与仿真  

Modelling and Emulation of Dosage Regimen for Intravenous Injection Combined with Oral Administration

作　　者：张燕 王东云 王子龙 庞留勇 赵中 ZHANG Yan;WANG Dongyun;WANG Zilong;PANG Liuyong;ZHAO Zhong(College of Chemistry and Pharmaceutical Engieering,Huanghuai University,Zhumadian 463000,China;Intelligent Manufacturing Institute,Huanghuai University,Zhumadian 463000,China;College of Mathematics and Statistics,Huanghuai University,Zhumadian 463000,China;College of Science,Xi’an Jiaotong-liverpool University,Suzhou 215000,China)

机构地区：[1]黄淮学院化学与制药工程学院,河南驻马店463000 [2]黄淮学院智能制造学院,河南驻马店463000 [3]黄淮学院数学与统计学院,河南驻马店463000 [4]西交利物浦大学理学院,江苏苏州215000

出　　处：《信阳师范学院学报（自然科学版）》2022年第4期528-532,682,共6页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(12171193);河南省科技计划项目(222102110028);河南省高等教育教学改革研究项目(2020JGLX075,2021SJGLX251Y);河南省高校重点科研项目(21A110015)。

摘　　要：研究了静脉注射联合口服给药方式的药代动力学模型,探讨了周期解的稳定性和联合给药方案设计的原理,并给出了联合给药方案设计的算法步骤。通过具体的算例,验证了设计方法的可行性和合理性。分析结果表明:联合给药方式能够使得给药方案的设计更加灵活,更有利于个体化给药方案的设计。A pharmacokinetic model with intravenous injection combined with oral administration is studied, the stability of periodic solution and the design principle of the combined drug administration scheme are investigated. Furthermore, the algorithm steps of the combined drug administration scheme are given. Through a specific example analysis, the feasibility and rationality of the method are verified. The results indicate that the combined drug administration could make the design of drug administration more flexible and conducive to the individual drug administration.

关 键 词：药代动力学模型 静脉注射 口服给药 一房室模型 建模与仿真 

分 类 号：O175[理学—数学] R969.1[理学—基础数学]