Targeting the Cuneiform Nucleus in Parkinson’s Disease: Option to Improve Locomotor Activity  

作　　者：Wei Cui Bao Xue Junxia Xie Huamin Xu 

机构地区：[1]Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders,School of Basic Medicine,Qingdao University,Qingdao,266071,China [2]Institute of Brain Science and Disease,Qingdao University,Qingdao,266071,China

出　　处：《Neuroscience Bulletin》2022年第8期976-978,共3页神经科学通报（英文版）

基　　金：This Highlight was supported by the National Natural Science Foundation of China(31871202,32170984);the Department of Science and Technology of Shandong Province(ZR2019MC057);Excellent Innovative Team of Shandong Province(2020KJK007);Taishan Scholars Construction Project of Shandong Province,China.

摘　　要：Parkinson's disease(PD)is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc),accompanied by severe locomotor deficits[1].Deep brain stimulation(DBS)mainly targeting the subthalamic nucleus and the internal segment of the globus pallidus has now been clinically used to improve the motor symptoms of PD patients.However,these targets do not relieve the serious postural instability and freezing of gait.The mesencephalic locomotor region(MLR)plays a key role in controlling locomotion[2,3].

关 键 词：STIMULATION FREEZING clinically 

分 类 号：R742.5[医药卫生—神经病学与精神病学]