血β2微球蛋白水平与脑微出血相关性的研究  

Study on the correlation between radioimmune kidney function and cerebral microbleeds

作　　者：刘玥[1] 党云[2] 张晓辉 赵嘉欣 唐鹏[1] 种莉[1] Liu Yue;Dang Yun;Zhang Xiaohui;Zhao Jiaxin;Tang Peng;Chong Li(Third Department of Neurology,the Shaanxi Provincial People's Hospital,Xian 710068,China)

机构地区：[1]陕西省人民医院神经内三科,西安710068 [2]西安医学院第一附属医院

出　　处：《脑与神经疾病杂志》2022年第10期642-645,共4页Journal of Brain and Nervous Diseases

基　　金：陕西省重点研发计划一般项目-社会发展领域(2020SF-332、2022SF-416)。

摘　　要：目的 研究脑微出血(CMBs)患者头颅磁共振SWI微出血病灶数量及部位与放射免疫法肾功能之间的相关性。方法 陕西省人民医院95例CMBs患者,入院后行血清肌酐、尿素氮及放射免疫法肾功能等生化检查,同时进行3.0T头颅磁共振SWI,记录其微出血病灶的数量及部位。结果 CMBs患者的放射免疫法测定肾功能与年龄、CMBs数量进行相关分析,结果发现血β2微球蛋白水平不仅与患者CMBs总数具有正相关性(r=0.249,P <0.05),同时与脑深部CMBs(r=0.241,P <0.05)及脑皮质CMBs(r=0.246,P<0.05)亦呈正相关性,差异均有统计学意义。结论 血β2微球蛋白水平与CMBs之间有明显相关性。Objective To evaluate the relationship between the radioimmune kidney function and the number and location of microbleeding lesions on cranial magnetic resonance SWI in patients with cerebral microbleeds(CMBs).Methods Ninety-five patients with CMBs in Shaanxi Provincial People’s Hospital underwent biochemical examinations such as serum creatinine,urea nitrogen,and renal function after admission.At the same time,3.0 T cranial magnetic resonance SWI was performed to record the number and location of microbleeding lesions.Results The serum β 2 microglobulin level was not only positively correlated with the total number of CMBs,which was statistically significant(r=0.249,P<0.05),but also significantly correlated with deep brain CMBs(r=0.241,P<0.05) and lobe CMBs(r=0.246,P<0.05).Conclusion There is a significant correlation between the serum β 2 microglobulin level and CMBs.

关 键 词：脑微出血 放射免疫法肾功能 血β2微球蛋白水平 

分 类 号：R743.32[医药卫生—神经病学与精神病学]