己糖激酶2(HK2)参与肿瘤发生发展的研究进展  

Research progress of hexokinase 2(HK2)involved in tumorigenesis and development

作　　者：卢妮 陈书德 宁怡婷 邱梦丹 邱霖 孙新策 李兰兰[2,3] LU Ni;CHEN Shude;NING Yiting;QIU Mengdan;QIU Lin;SUN Xince;LI Lanlan(The Second Clinical Medical College of Lanzhou University,Lanzhou 7300oo,China;Key Laboratory of Urological Disease of Gansu Province,Lanzhou University Second Hospital,Lanzhou 730030,China;Institute of Gansu Nephronrological Clinical Center,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二临床医学院,兰州730000 [2]兰州大学第二医院甘肃省泌尿系统疾病研究重点实验室,兰州730030 [3]兰州大学第二医院甘肃省泌尿系疾病临床医学中心,兰州730030

出　　处：《生命的化学》2022年第8期1502-1509,共8页Chemistry of Life

基　　金：国家自然科学基金青年基金项目(82002678);兰州大学中央高校基本科研业务费专项(lzujbky-2021-kb29);甘肃省科技计划青年科技基金计划项目(20JR5RA319);甘肃省高等学校创新基金项目(2020B-035)。

摘　　要：糖酵解是一个严格调控的过程,己糖激酶(hexokinase,HK)在其中起着至关重要的作用。己糖激酶的几种同工酶在不同肿瘤细胞不同能量代谢途径中具有特定的表达水平,这些特征性的代谢途径为肿瘤的干预治疗提供了可能。其中,同工酶HK2与肿瘤细胞的能量代谢密切相关,并在多种肿瘤细胞中呈现过度表达,提示其参与了肿瘤发生发展甚至转移过程。本文通过对HK2与肿瘤相关的研究进行综述,进而揭示HK2与肿瘤发生发展的相关性,以期为靶向HK2肿瘤治疗提供理论指导。Glycolysis is a strictly regulated process in which hexokinase(HK)plays an important role.Several isozymes of hexokinase have specific expression levels in different energy metabolism pathways of different tumor cells.These characteristic metabolic pathways provide the possibility for tumor intervention and treatment.Among them,the isozyme HK2 is closely related to the energy metabolism of tumor cells,and is overexpressed in a variety of tumor cells,suggesting that it is involved in the occurrence,development and even metastasis of tumors.This paper reviews the research on the relationship between HK2 and tumor,and then reveals the relationship between HK2 and tumor occurrence and development,in order to provide theoretical guidance for targeted HK2 tumor therapy.

关 键 词：己糖激酶 HK2 肿瘤 糖代谢 

分 类 号：R730.2[医药卫生—肿瘤]