散发型CEBPA双突变急性髓系白血病患者复发后克隆衍变3例报道并文献复习  

Clonal evolution of three patients with acute myeloid leukemia with sporadic CEBPA double mutations:case report and a literature review

作　　者：李映 张云蔚[2] 宋飞[2] 苏龙[2] 高素君[2] Li Ying;Zhang Yunwei;Song Fei;Su Long;Gao Sujun(Department of Hematology,Changchun Central Hospital,Changchun 130041,Jilin,China;Department of Hematology,the First Hospital of Jilin University,Changchun 130021,Jilin,China)

机构地区：[1]长春市中心医院血液科,吉林长春130041 [2]吉林大学第一医院血液科,吉林长春130021

出　　处：《中国医学前沿杂志（电子版）》2022年第10期46-48,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：吴阶平医学基金会临床科研专项基金资助(320.6750.2020-12-05)。

摘　　要：急性髓系白血病(acute myeloid leukemia,AML)伴CEBPA双突变预后良好,但复发风险较高。本文总结3例经标准治疗缓解后复发的CEBPA双突变AML患者,通过对比初诊及复发后骨髓白血病细胞基因突变结果,进而探讨此类白血病复发后克隆衍变模式,以期为优化临床患者管理提供参考。Acute myeloid leukemia(AML) with CEBPA double mutations is associated with favorable prognosis.However,the relapse risk is high if the patients treated with current chemotherapy-based strategies.In this case report,three patients with CEBPA double mutations relapsed after remission.The paired bone marrow samples of diagnosis and relapse were screened for genetic mutations in order to summary the clonal evolution patterns of such kind of leukemia.The results may be beneficial for optimizing the management of clinical patients.

关 键 词：急性髓系白血病 CEBPA双突变 复发 克隆衍变 

分 类 号：R733.71[医药卫生—肿瘤]