血清白介素-10、胸苷激酶1在急性淋巴细胞白血病患儿中的表达及与危险度分层的相关性  

CSerum Interleukin-10 and Thymidine Kinase 1 Levels and Their Correlation with Risk Stratification in Children with Acute Lymphoblastic Leukemia

作　　者：宋春艳 林云碧 雷庆龄 吕瑜 肖祖刚 SONG Chun-yan;LIN Yun-bi;LEI Qing-ling(Department of Hematology and Oncology,Children's Hospital Affiliated to Kunming Medical University/Kunming Children's Hospital,Kunming,Yunnan 650000)

机构地区：[1]昆明医科大学附属儿童医院/昆明市儿童医院血液肿瘤科,650000

出　　处：《临床输血与检验》2022年第5期621-625,共5页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的观察血清白介素(IL)-10、胸苷激酶1(TK1)在急性淋巴细胞白血病(ALL)患儿中的表达情况,并分析二者与ALL患儿危险度分层的关系。方法选取2018年5月~2021年5月医院收治的100例ALL患儿作为研究对象,全部患儿均评估危险度分层,并调查患儿基线资料,检测患儿血清IL-10、TK1等实验室指标,分析血清IL-10、TK1在ALL患儿中的表达情况及其与危险度分层的关系。结果全部患儿均接受危险度分层评估,其中24例标危,50例中危,26例高危,占比分别为24.00%,50.00%,26.00%;3组基线资料对比,差异无统计学意义(P>0.05);高危组的IL-10、TK1及白细胞(WBC)计数均高于标危组和中危组,且组间两两比较,差异有统计学意义(P<0.05);采用Kendall's tau-b相关性分析结果显示,ALL患儿血清IL-10、TK1及WBC计数与危险度分层之间呈正相关(r>0,P<0.05);建立多元Logistic回归分析结果显示,以高危组为参照,血清IL-10、TK1及WBC计数降低时,ALL患儿危险度分层低的可能性分别为7.128倍、13.572倍及1.665倍(P<0.05)。结论血清IL-10、TK1在ALL患儿中存在异常表达,且与危险度分层存在相关性。Objective To determine serum interleukin(IL)-10 and thymidine kinase 1(TK1)levels in children with acute lymphoblastic leukemia(ALL),and analyze the relationship between the two and risk stratification in ALL children.Methods A total of 100 ALL children admitted at hospital from May 2018 to May 2021 were selected.All pediatric patients were evaluated for risk stratification,and we investigated the baseline data.Serum IL-10,TK1,as well as other laboratory indexes were detected.The expression of serum IL-10 and TK1,and the relationship between the two levels and risk stratification were performed.Results ALL children were evaluated for risk stratification,of which 24 cases had standard-risk,50 cases had medium-risk and 26 cases had high-risk,accounting for 24.00%,50.00%and 26.00%respectively.There was no statistically significant difference between the three groups of baseline data(P>0.05).The levels of IL-10,TK1 and white blood cell(WBC)count in high-risk group were higher than those in standard-risk group and medium-risk group,and there was a statistically significant differences between the two groups(P<0.05).Using Kendall's tau-b,we found positive correlation between serum IL-10,TK1 and WBC count were associated with risk stratification in ALL children(r>0,P<0.05).Multivariate Logistic regression analysis revealed that when serum IL-10,TK1 and WBC counts decreased,the probability of risk stratification in ALL children was 7.128 times,13.572 times and 1.665 times,respectively,compared with high-risk group(P<0.05).Conclusion Serum IL-10 and TK1 are abnormally expressed in ALL children and are positively correlated with risk stratification.

关 键 词：急性淋巴细胞白血病 危险度分层 白介素-10 胸苷激酶1 相关性 

分 类 号：R733.71[医药卫生—肿瘤]