KISS-1、P16和SCC-Ag在宫颈癌组织中的表达及意义  

Expression and Significance of KiSS-1,p16 and SCC Ag in Cervical Cancer

作　　者：杨弋弋[1] 周新欢[1] 邹科 倪鸣[1] 孙君华 YANG Yiyi;ZHOU Xinhuan;ZOU Ke(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2022年第10期1578-1582,共5页The Practical Journal of Cancer

摘　　要：目的 探讨转移抑制基因(KISS-1)、抑癌基因P16、鳞状细胞癌抗原(SCC-Ag)在宫颈癌组织中的表达及意义。方法 选取宫颈癌患者150例作为研究对象,采用免疫组织化学法(SP)检测宫颈癌及其癌旁正常组织中的KISS-1、P16和SCC-Ag的表达,分析其与临床病理特征以及患者预后的关系,并探讨它们之间阳性表达的相关性。结果 宫颈癌组织中的P16和SCC-Ag阳性表达高于癌旁正常组织,KISS-1阳性表达低于癌旁正常组织(P<0.05)。宫颈癌组织中KISS-1、P16和SCC-Ag的阳性表达与年龄、病理类型无关(P>0.05),与肿瘤大小、TNM分期、浸润深度、淋巴结转移有关(P<0.05)。生存曲线分析显示,KISS-1阳性表达患者3年生存率为78.05%,高于其阴性表达患者的59.63%;P16阳性表达患者3年生存率为60.17%,低于其阴性表达患者的81.25%;SCC-Ag阳性表达患者3年生存率为60.18%,低于其阴性表达患者的78.38%(χ~2=4.254,P<0.05;χ~2=4.605,P<0.05;χ~2=4.041,P<0.05)。Spearman秩相关结果显示,KISS-1表达与P16、SCC-Ag的表达呈负相关(γ=-0.510;γ=-0.668,P<0.05),P16表达与SCC-Ag的表达呈正相关(γ=0.373,P<0.05)。结论 P16和SCC-Ag在宫颈癌组织中的阳性表达升高,KISS-1阳性表达降低,且能够反映癌细胞浸润和转移,可作为宫颈癌诊断和预后评估的生物标志物。Objective To investigate the expression and significance of metastasis suppressor gene(KiSS-1),tumor suppressor gene p16 and squamous cell carcinoma antigen(SCC Ag) in cervical cancer.Methods 150 patients with cervical cancer diagnosed and treated were selected as the research object.The expressions of KiSS-1,p16 and SCC Ag in cervical cancer and its adjacent normal tissues were detected by immunohistochemical method(SP).The relationship between KiSS-1,p16 and SCC Ag and clinicopathological features and prognosis were analyzed,and the correlation between their positive expression was discussed.Results the positive expressions of p16 and SCC Ag in cervical cancer tissues were higher than those in adjacent normal tissues,and the positive expression of KiSS-1 was lower than that in adjacent normal tissues(P0.05),but related to tumor size,TNM stage,depth of invasion and lymph node metastasis(P<0.05);Survival curve analysis showed that the 3-year survival rate of KiSS-1 positive patients was 78.05%,which was higher than 59.63% of KiSS-1 negative patients;The 3-year survival rate of patients with positive p16 expression was 60.17%,which was lower than 81.25% of patients with negative p16 expression;The 3-year survival rate of patients with SCC Ag positive expression was 60.18%,which was lower than 78.38% of patients with SCC Ag negative expression( χ~2=4.254,P<0.05;χ~2=4.605,P<0.05;χ~2=4.041,P<0.05);Spearman rank correlation showed that the expression of KiSS-1 was negatively correlated with the expression of p16 and SCC Ag(γ=-0.510;γ=-0.668,P<0.05),the expression of p16 was positively correlated with the expression of SCC Ag(γ=0.373,P<0.05).Conclusion The positive expression of p16 and SCC Ag increased and the positive expression of KiSS-1 decreased in cervical cancer,which can reflect the progress of cancer cell infiltration and metastasis.It can be used as a useful biomarker for the diagnosis of cervical precancerous lesions.

关 键 词：宫颈癌 KISS-1 P16 SCC-AG 

分 类 号：R737.33[医药卫生—肿瘤]