原发性胃肠道恶性淋巴瘤术后生存期的影响因素与TNM分期对远期生存的预测作用  

Postoperative Survival Factors of Primary Gastrointestinal Malignant Lymphoma and Prediction Effect of TNM Stage on Long-term Survival

作　　者：焦元元[1] 马琳[1] 孙紫萍 JIAO Yuanyuan;MA Lin;SUN Ziping(Henan Cancer Hospital,Zhengzhou,450000)

机构地区：[1]河南省肿瘤医院,450000

出　　处：《实用癌症杂志》2022年第10期1722-1725,共4页The Practical Journal of Cancer

摘　　要：目的 探讨原发性胃肠道恶性淋巴瘤术后生存期的影响因素与TNM分期对远期生存的预测作用。方法 回顾性分析90例原发性胃肠道恶性淋巴瘤患者的临床资料,入选者均进行手术治疗,并进行长期随访。根据5年随访结果将患者分为生存组与病死组,统计两组患者一般资料,分析影响患者术后生存期的危险因素。利用Kaplan-Meier绘制生存曲线图,分析TNM分期对患者远期生存率的预测价值。结果 随访5年,90例患者中,存活55例(61.11%),病死35例(38.89%);病死组远处转移、TNM分期Ⅳ期占比均高于生存组,差异有统计学意义(P<0.05);两组性别、年龄、疾病类型、发病部位、饮酒史、吸烟史等对比,差异无统计学意义(P>0.05);Logistic回归分析:远处转移、TNM分期是原发性胃肠道恶性淋巴瘤术后生存期的独立危险因素(P<0.05且OR≥1);利用Kaplan-Meier绘制不同分期患者的生存曲线发现,TNM分期评估患者远期生存期的95%CI:46.284~52.375,中位生存期为48.22个月。结论 原发性胃肠道恶性淋巴瘤患者远期预后并不理想,远处转移、TNM分期是影响患者生存期的独立因素,TNM分期对患者远期生存期有理想的预测价值。Objective To explore the factors influencing survival after primary gastrointestinal malignant lymphoma and the predicted effect of TNM stage on long-term survival.Methods The clinical data of 90 patients with primary gastrointestinal malignant lymphoma were analyzed retrospectively,with surgical treatment and long-term follow-up.Patients were divided into survival and mortality groups according to the 5-year follow-up results.General data of the 2 groups were counted and risk factors affecting postoperative survival were analyzed.The survival curves were drawn using Kaplan-Meier to analyze the predictive value of TNM stage on long-term survival.Results Follow-up for 5 years,Of the 90 patients,survived 55(61.11%),35 cases died(38.89%);The proportion of distant metastasis and TNM stage period was higher than that in the survival group,Differences were statistically significant(P0.05);Logistic regression analysis:distant metastasis and TNM stage were independent risk factors for survival after primary gastrointestinal malignant lymphoma(P<0.05 and OR≥ 1);Kaplan-Meier was used to plot survival curves for patients with different stages and found,TNM staging assessed the 95% CI of forward survival 46.284~52.375,Median survival was 48.22 months.Conclusion Long-term prognosis of patients with primary gastrointestinal malignant lymphoma is not ideal.Remote metastasis and TNM stage are independent factors affecting patient survival,and TNM stage has ideal predictive value for patient long-term survival.

关 键 词：原发性胃肠道恶性淋巴瘤 术后生存期 影响因素 TNM分期 远期生存 

分 类 号：R735[医药卫生—肿瘤]