维生素D缺乏与多囊卵巢综合征研究进展  

Progress on the relationship between vitamin D deficiency and polycystic ovary syndrome

作　　者：吴婷婷[1,2] 周加敏 许波群 WU Ting-ting;ZHOU Jia-min;XU Bo-qun(Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210000,China;不详)

机构地区：[1]南京医科大学第二附属医院妇产科,江苏南京210000 [2]南京市红十字医院妇产科,江苏南京210000 [3]南京医科大学附属逸夫医院妇产科,江苏南京210000

出　　处：《中国临床研究》2022年第10期1439-1443,共5页Chinese Journal of Clinical Research

基　　金：国家自然科学基金项目(81873820);南京市卫生科技发展专项资金项目(YKK19150)。

摘　　要：维生素D在许多骨骼外疾病方面具有潜在作用,包括癌症、自身免疫性疾病、心血管疾病、糖尿病和肥胖。维生素D是一种前激素,需要代谢成生物活性产物,与其同源核受体[维生素D受体(VDR)]结合,以调节不同的生理过程。VDR存在于生殖系统,如子宫、卵巢等组织。近来研究发现维生素D缺乏与多囊卵巢综合征(PCOS)相关。PCOS常伴有不孕、胰岛素抵抗和血脂异常等代谢功能障碍。维生素D状态与PCOS患者的卵泡发育障碍、代谢障碍、心血管疾病和心理健康等有关,补充维生素D治疗后可能会改善PCOS引起的胰岛素抵抗、高雄激素血症及肥胖。本文就维生素D缺乏和PCOS之间关系的研究进展作一简要综述,探讨PCOS患者维生素D缺乏可能的作用机制,为PCOS的临床治疗提供思路。Vitamin D has a potential role in many extraskeletal diseases,including tumors,autoimmune diseases,cardiovascular disease,diabetes,and obesity.Vitamin D is a prohormone that needs to be metabolized into bioactive products and bind to its homologous nuclear receptor [vitamin D receptor(VDR)] to regulate different physiological processes.VDR exists in the reproductive system,such as uterus,ovary and other tissues.Recent studies have found that vitamin D deficiency is associated with polycystic ovary syndrome(PCOS).PCOS is often accompanied by infertility,metabolic dysfunction such as insulin resistance and dyslipidemia.Vitamin D level is associated with follicular dysplasia,metabolic disorders,cardiovascular disease and mental health in PCOS patients.Supplementation of vitamin D may improve insulin resistance,hyperandrogenemia and obesity caused by PCOS.This paper briefly reviews the research progress on the relationship between vitamin D and PCOS,explores the possible mechanism of vitamin D deficiency in PCOS patients,and provides ideas for the clinical treatment of PCOS.

关 键 词：维生素D 多囊卵巢综合征 卵泡发育障碍 代谢障碍 心血管疾病 心理障碍 维生素D受体基因多态性 

分 类 号：R771.75[医药卫生—眼科]