Hige namine as a Potential Pharmacologic Stress Age nt in the Detection of Coro nary Artery Disease  

去甲乌药碱:一种潜在的冠心病诊断心肌负荷药物

作　　者：Nana Zhang Zijian Li Haibo Zhu 张娜娜;李子健;朱海波(中国农业科学院农产品加工研究所,北京100091;北京大学第三医院心内科、血管医学研究所,卫生部心血管分子生物学与调节肽重点实验室,分子心血管学教育部重点实验室,心血管受体研究北京市重点实验室,北京100191;中国医学科学院北京协和医学药物研究所,天然药物活性物质与功能国家重点实验室新药作用机制研究与药效学评价北京重点实验室,北京100007)

机构地区：[1]Unstitute of Food Scienee and Technology,Chinese Academy of Agricultural Sciences,Beijing 100050,China [2]Institute of Vascular Medicine,Peking University Third Hospital,Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health,Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education,and Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100050,China [3]State Key Laboratory for Bioactive Substances and Functions of Natural Medicines,Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Medical Sciences Journal》2022年第3期275-281,I0014,共8页中国医学科学杂志（英文版）

基　　金：中国医学科学院医学与健康科技创新工程(2021-1-I2M-028)。

摘　　要：Myocardial perfusion imaging(MPI) is valuable for the diagnosis,prognosis,and management of coronary artery disease(CAD).The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents.However,these agents have contraindications and may cause adverse effects in some patients.Thus,other stress agents feasible for more patients are required.Higenamine(HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction.It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies.This review summarizes the application of HG on MPI,including its mechanism of action,stress protocol,efficacy,and safety.

关 键 词：coronary artery disease HIGENAMINE myocardial perfusion imaging stress agent 

分 类 号：R972[医药卫生—药品]