HIGENAMINE

作品数：6被引量：34H指数：2
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相关领域：医药卫生更多>>
相关作者：许佑君刘维新更多>>
相关机构：中国医科大学沈阳药科大学更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Chinese Medical Sciences Journal》《Natural Products and Bioprospecting》更多>>
相关基金：国家高技术研究发展计划国家自然科学基金International Foundation for Science更多>>
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Hige namine as a Potential Pharmacologic Stress Age nt in the Detection of Coro nary Artery Disease
《Chinese Medical Sciences Journal》2022年第3期275-281,I0014,共8页Nana Zhang Zijian Li Haibo Zhu 
中国医学科学院医学与健康科技创新工程(2021-1-I2M-028)。
Myocardial perfusion imaging(MPI) is valuable for the diagnosis,prognosis,and management of coronary artery disease(CAD).The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic ag...
关键词：coronary artery disease HIGENAMINE myocardial perfusion imaging stress agent 
A novel β_(2)-AR agonist,Higenamine,induces β-arrestin-biased signaling被引量：1
《Science China(Life Sciences)》2022年第7期1357-1368,共12页Nana Zhang Haibo Zhu Zijian Li Erdan Dong 
supported by the National Natural Science Foundation of China(91939301,81820108031,82070235);Beijing Municipal Natural Science Foundation(7172235,7191013);Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases,Chinese Academy of Medical Sciences(2021RU003);CAMS Innovation Fund for Medical Sciences(2021-1-I2M028);Disciplines construction project for multi-omics pharmacology(201920200807)。
The biased ligands in G protein-coupled receptors(GPCRs)have opened new avenues for developing safer and more effective drugs.However,the identification of such biased ligands as drug candidates is highly desirable.He...
关键词：HIGENAMINE β_(2)-adrenergic receptor β-arrestin-biased signaling extracellular signal-regulated kinase 1/2 
Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model被引量：1
《Natural Products and Bioprospecting》2018年第1期63-69,共7页Paul Erasto Richard Sunguruma Joan J.Munissi Victor Wiketye Charles de Konig Atallah F.Ahmed 
supported by the International Foundation for Science(IFS)Grant Number J/4894-2.
The Phytochemical investigation on MeOH extract on the bark of Aristolochia brasiliensis Mart.&Zucc(Aristolochi-aceae)led to the isolation of major compound(1)as light brown grainy crystals.The compound was identified...
关键词：Aristolochia brasiliensis Galleria mellonella HIGENAMINE ISONIAZID Mycobacterium indicus pranii Antimycobacterial activity 
A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects被引量：10
《Acta Pharmacologica Sinica》2012年第11期1353-1358,共6页Sheng FENG Ji JIANG Pei HU Jian-yan ZHANG Tao LIU Qian ZHAO Bi-lu LI 
Aim： To investigate the pharmacokinetics, pharmacodynamics, and safety of higenamine, an active ingredient of Aconite root, in healthy Chinese volunteers. Methods：Ten subjects received continuous, intravenous infusi...
关键词：HIGENAMINE Aconite root coronary artery disease stress myocardial perfusion imaging pharmacologic stress test pharma-cokinetics PHARMACODYNAMICS 
Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist被引量：24
《Acta Pharmacologica Sinica》2008年第10期1187-1194,共8页Gang BAI Yang YANG Qian SHI Ze LIU Qi ZHANG Yuan-yuan ZHU 
This work was supported in part by grants from the National High Technology Research and Development Program of China （863 Program） （No 2006AA020502）, and the Natural Science Foundation of Tianjin, China （No 07JCZDJC05000）. Author contribution Gang BAI designed research; Yang YANG, Qian SHI, and Ze LIU performed research; Yuan-yuan ZHU contributed new analytical tools and analyzed data; Qi ZHANG and Yang YANG wrote the paper.
Aim： To screen beta2-adrenergic receptor Lateralis Preparata （RALP） as potential （β2-AR） agonists from Radix Aconiti drug leads for asthma using a sensitive cell-based agonist assay. Methods： The β2-AR gene wa...
关键词：beta2-adrenergic receptor （β2-AR） agonists ASTHMA herbal medicines Radix Aconiti Lateralis Preparata （RALP） HIGENAMINE 
附子强心成分Higenamine及其结构
《国际药学研究杂志》1975年第2期118-118,共1页林文超 
最近,作者分离得混杂在 yokonoside 中的微量强心成分,将之稀释至10-9浓度时,仍显示强心活性。此成分为无色板状结晶,熔点260°,为水溶性异喹啉类生物碱,定名为 higenamine 盐酸盐,结构式为:
关键词：强心 HIGENAMINE 
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