Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus  

作　　者：Xi Yu Gong Cheng 

机构地区：[1]Tsinghua-Peking Center for Life Sciences,School of Medicine,Tsinghua University,Beijing,China [2]Institute of Infectious Diseases,Shenzhen Bay Laboratory,Shenzhen,China [3]Institute of Pathogenic Organisms,Shenzhen Center for Disease Control and Prevention,Shenzhen,China [4]School of Life Sciences,Tsinghua University,Beijing,China

出　　处：《Animal Models and Experimental Medicine》2022年第5期410-417,共8页动物模型与实验医学（英文）

基　　金：National Key Research and Development Plan of China,Grant/Award Number:2018YFA0507202,2020YFC1200100 and 2021YFC2300200;National Natural Science Foundation of China,Grant/Award Number:31825001,32188101,81730063,81961160737 and 82102389;Provincial Innovation Team for the Prevention and Control of Highly Pathogenic Pathogens,Institute of Medical Biology,Chinese Academy of Medical Sciences,Grant/Award Number:202105AE160020;Shenzhen San-Ming Project for Prevention and Research on Vector-borne Diseases,Grant/Award Number:SZSM201611064;Shenzhen Science and Technology Project,Grant/Award Number:JSGG20191129144225464;Tsinghua University Spring Breeze Fund,Grant/Award Number:2020Z99CFG017;Young Elite Scientists Sponsorship Program,Grant/Award Number:2021QNRC001;Yunnan Cheng Gong Expert Work-Station,Grant/Award Number:202005AF150034。

摘　　要：Dengue virus(DENV)is one of the most important arboviral pathogens in the tropics and subtropics,and nearly one-third of the world's population is at risk of infection.The transmission of DENV involves a sylvatic cycle between nonhuman primates(NHP)and Aedes genus mosquitoes,and an endemic cycle between human hosts and predominantly Aedes aegypti.DENV belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes(DENV-1-4).Phylogenetic analyses of DENV have revealed its origin,epidemiology,and the drivers that determine its molecular evolution in nature.This review discusses how phyloge-netic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence.

关 键 词：dengue virus(DENV) EVOLUTION FLAVIVIRUS PHYLOGENETICS 

分 类 号：R512.8[医药卫生—内科学] R181.3[医药卫生—临床医学]