The effects of inactivated SARS-CoV-2 vaccination and subsequent infection of pregnant mice on the behaviors of offspring  

作　　者：Kaili Lin Meixuan Liu Lu Sun Hongwei Qiao Shunyi Wang Sidan Pan Hanjun Fu Jingzhu Wang Qiang Wei Hong Gao 

机构地区：[1]Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College,Beijing,China

出　　处：《Animal Models and Experimental Medicine》2022年第5期430-435,共6页动物模型与实验医学（英文）

基　　金：National Key Research and Development Project of China,Grant/Award Number:2020YFA0707600。

摘　　要：The mass inoculation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines to induce herd immunity is one of the most effective measures we can deploy in the fight against coronavirus disease 2019(COVID-19).Pregnant women are prone to a higher risk of COVID-19,and maternal infection is a risk fac-tor for a range of neurological disorders leading to abnormal behavior in adulthood.However,there are limited clinical data to support whether vaccination or infection post-immunization in pregnant women can affect the behavioral cognition of fetuses in adulthood.In this study,human angiotensin-converting enzyme 2 pregnant mice(F0 generation)were immunized with CoronaVac and then infected with SARS-CoV-2.Subsequently,we analyzed the behavioral cognition of their adult offspring(F1 gen-eration)using the open-field test and Morris water maze test.The adult F1 generation did not exhibit any impairments in spontaneous locomotor activity or spatial refer-ence memory.

关 键 词：OFFSPRING spatial reference memory spontaneous locomotor activity 

分 类 号：R186[医药卫生—流行病学]