复发性髓母细胞瘤患者预后的影响因素分析  

Analysis of the influencing factors for prognosis of patients with recurrent medulloblastoma

作　　者：王琳[1] 宁绍爽 张俸萁 李国文[1] 刘新奎[4] WANG Lin;NING Shaoshuang;ZHANG Fengqi;LI Guowen;LIU Xinkui(WardⅡ,Department of Radiotherapy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,He’nan,China;Department of Medical Technology,Nanyang Medical College,Nanyang 473000,He’nan,China;Department of Oncology Radiotherapy,the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471000,He’nan,China;Department of Medical Records Management,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,He’nan,China)

机构地区：[1]郑州大学第一附属医院放疗二科,郑州450052 [2]南阳医学高等专科学校医学技术系,河南南阳473000 [3]河南科技大学第一附属医院肿瘤放疗科,河南洛阳471000 [4]郑州大学第一附属医院病案管理科,郑州450052

出　　处：《癌症进展》2022年第18期1872-1875,共4页Oncology Progress

基　　金：河南省医学科技攻关计划省部共建项目(SB201901021)。

摘　　要：目的探讨复发性髓母细胞瘤(rMB)患者预后的影响因素。方法收集56例rMB患者的病历资料,包括病理分型、危险度、复发部位及复发后是否手术、化疗、放疗等。比较不同临床特征rMB患者的中位总生存期(OS),采用多因素Cox比例风险回归模型分析rMB患者OS的影响因素。结果56例rMB患者的中位OS为12.85个月。单因素分析结果显示,病理分型、危险度、复发后再程放疗、复发后化疗可能不是rMB患者OS的影响因素(P﹥0.05);复发部位、复发后手术均可能是rMB患者OS的影响因素(P﹤0.01)。多因素分析结果显示,复发部位、复发后手术均是rMB患者OS的独立影响因素(P﹤0.05)。结论rMB患者的OS较短,且与复发部位、复发后是否手术相关,应重视首次治疗,尽可能控制疾病复发。一旦复发,在条件允许的情况下尽可能手术。Objective To investigate the prognostic factors of patients with recurrent medulloblastoma(rMB).Method The clinical data of 56 patients with rMB were collected,including pathological type,degree of risk,recurrence site,and whether surgery,chemotherapy,or radiotherapy after recurrence.The median overall survival(OS)of rMB patients with different clinical characteristics were compared.Multivariate Cox proportional hazards regression model was used to analyze the influencing factors for OS in rMB patients.Result The median OS of 56 patients with rMB was12.85 months.Univariate analysis showed that pathological type,degree of risk,re-radiotherapy after recurrence,and chemotherapy after recurrence may not be the risk factors for OS in patients with rMB(P>0.05);the recurrence site and surgery after recurrence may be the risk factors for OS in patients with rMB(P<0.01).The results of multivariate analysis showed that the recurrence site and surgery after recurrence were independent risk factors for OS in patients with rMB(P<0.05).Conclusions The OS of rMB patients is short,and it is related to the recurrence site and whether surgery is performed after recurrence.More attention should be paid to the primary treatment to control disease recurrence as much as possible.If recurrence occurs,surgery should be performed if the condition meets the requirement.

关 键 词：复发性髓母细胞瘤 复发部位 手术 预后 

分 类 号：R739.41[医药卫生—肿瘤]