酒精性肝病研究进展  

Progress on alcoholic liver disease

作　　者：李玥[1] 杨松[1] Li Yue;Yang Song(Center of Hepatology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院肝病中心,北京100015

出　　处：《中国肝脏病杂志（电子版）》2022年第3期1-4,共4页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家科技重大专项课题(2018ZX10715-005);北京市属医院科研培育计划(PX2022071);中国肝炎防治基金会天晴肝病研究基金(TQGB20210050)。

摘　　要：酒精性肝病(alcoholic liver disease,ALD)是危害我国人民健康的主要肝脏疾病之一。党的十八大以来,我国肝病领域研究人员与全球同道一起围绕ALD进行深入研究并取得重要进展。在ALD发病机制领域,进一步阐明了基因多态性、肠道微生态和铁死亡在酒精性肝病中的重要作用。在ALD诊疗领域,针对ALD维持戒酒、重症酒精性肝炎药物治疗及ALD肝移植等方面工作不断突破。但我国ALD防控形势依旧严峻,仍需针对ALD的发病机制与诊疗进行深入研究,以期切实改善ALD患者预后,进一步降低ALD的社会负担。Alcoholic liver disease(ALD)is one of the major liver diseases endangering the health of Chinese.Since the 18th National Congress of the Communist Party of China,Chinese and global researchers in hepatology conducted comprehensive research and made significant progress in ALD.In area of pathogenesis,studies further clarify the role of gene polymorphism,intestinal microecology and ferroptosis in pathogenesis of ALD.As for management of ALD,continuous breakthroughs have been made in areas of abstinence maintaining,treatment for severe alcoholic hepatitis,and liver transplantation for ALD.Yet,the situation of prevention and control of ALD in China is still a challenge.Comprehensive researches in pathogenesis and management of ALD are needed to effectively improve the prognosis of ALD patients and further reduce the social burden of ALD.

关 键 词：酒精性肝病 酒精性肝炎 铁死亡 阿坎酸 肝移植 

分 类 号：R575.5[医药卫生—消化系统]