代谢相关脂肪性肝病相关肝癌研究进展  

Progress on metabolic associated fatty liver disease related liver cancer

作　　者：蒋婷婷 孙芳芳 曾湛 李明慧 谢尧[1,2] Jiang Tingting;Sun Fangfang;Zeng Zhan;Li Minghui;Xie Yao(Department of Hepatology Division 2,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Department of Hepatology Division 2,Peking University Ditan Teaching Hospital,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院肝病二科,北京100015 [2]北京大学地坛医院教学医院肝病二科,北京100015

出　　处：《中国肝脏病杂志（电子版）》2022年第3期14-17,共4页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家科技重大专项(2017ZX10203202-003、2017ZX10201201-001-006、2017ZX10201201-002-006、2018ZX10715-005-003-005);首都临床特色专项资助项目(Z151100004015122);北京市医管中心临床专项项目(XMLX201706、XMLX202127);北京市医管中心消化协同中心资助项目(XXT28、XZ0302);北京市科委课题(D161100002716002)。

摘　　要：目前代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)已累及全球约1/3人口,是世界上最常见的慢性肝脏疾病之一。近年来,随着肥胖和代谢综合征的流行,MAFLD发病率呈上升趋势,MAFLD相关肝癌患者也日益增多。因此,明确MAFLD与肝癌间的关系尤为重要。本文从MAFLD相关肝癌的流行病学、发病机制、与病毒性肝炎的关系、危险因素、临床特点和诊断、防治进行综述,以期为MAFLD相关肝癌的防治工作提供帮助。Metabolic associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases in the world,affecting about 1/3 of the global population at present.In recent years,with the prevalence of obesity and metabolic syndrome,the incidence of MAFLD has been gradually on the rise,and the number of patients with MAFLD-related hepatocellular carcinoma(HCC)is also increasing.Due to the effective prevention and treatment of viral hepatitis,MAFLD has gradually become an important cause of HCC.Therefore,it is particularly important to identify the relationship between MAFLD and HCC.This article reviewed the epidemiology,pathogenesis,relationship with viral hepatitis,risk factors,clinical features,diagnosis,prevention and treatment of MAFLD-related HCC,in order to provide help for its prevention and treatment.

关 键 词：代谢相关脂肪性肝病 肝癌 危险因素 临床特点 预防与治疗 

分 类 号：R735.7[医药卫生—肿瘤] R575.5[医药卫生—临床医学]