肝纤维化可逆转动物模型研究进展  

Research progress on reversible animal model of liver fibrosis

作　　者：杜文涛 任万雷 胡豆豆[3] 许雅洁 尤文铮 姜相君[3] Du Wentao;Ren Wanlei;Hu Doudou;Xu Yajie;You Wenzheng;Jiang Xiangjun(School of Clinical Medicine,Weifang Medical University,Weifang 261053,Shandong Province,China;First Department of Traditional Chinese Medicine,Qingdao Central Hospital Affiliated to Qingdao University,Qingdao 266042,Shandong Province,China;Department of Gastroenterology,Qingdao Municipal Hospital,Qingdao 266011,Shandong Province,China)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261053 [2]青岛大学附属青岛市中心医院中医一科,山东青岛266042 [3]青岛市市立医院消化内科,山东青岛266011

出　　处：《中国肝脏病杂志（电子版）》2022年第3期18-21,共4页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家自然科学基金青年科学基金项目(81800543)。

摘　　要：肝硬化是各种肝脏疾病的终末阶段,肝硬化能否逆转已争议多年,越来越多的证据表明,肝硬化在去除病因、得到有效治疗后可发生一定程度的逆转。肝纤维化是各种慢性肝病发展为肝硬化的重要中间环节,具有修复和损伤双重性,肝纤维化可进一步发展为肝硬化甚至肝癌,严重威胁患者生命。因此,肝纤维化逆转的研究对于临床诊治具有重要的指导意义。动物实验是生物医学研究的基本手段之一,也是连接基础研究和临床试验的重要桥梁,本文总结不同动物模型包括化学损伤性肝纤维化逆转模型、胆管结扎肝纤维化逆转模型和非酒精性脂肪性肝纤维化逆转模型等,通过归纳不同动物模型的优点与局限性,为肝纤维化逆转研究提供依据,以更好地指导临床实践。Liver cirrhosis is the final stage of various liver diseases. Whether liver cirrhosis can be reversed has been debated for many years. More and more evidence showed that liver cirrhosis could be reversed to a certain extent after removing the etiology and receiving effective treatment. Liver fibrosis is an important intermediate link in the development of various chronic liver diseases into liver cirrhosis. It has the dual nature of repair and injury, and liver fibrosis can furtherly develop into liver cirrhosis and even liver cancer,and it is a serious threat to the patients. Therefore, the study of liver fibrosis reversal put a very important guiding significance to the diagnosis and treatment of clinical patients with liver cirrhosis. Animal experiment is not only one of the basic means of biomedical research, but also an important bridge between basic research and clinical trials. This paper summarized different animal models, including chemical injury liver fibrosis reversal model, bile duct ligation liver fibrosis reversal model and non-alcoholic fatty liver fibrosis reversal model by summarizing the advantages and limitations of different animal models, and provide evidence for reversal study of liver fibrosis to better guide clinical practice.

关 键 词：肝纤维化逆转 动物模型 化学损伤性肝纤维化逆转模型 胆管结扎肝纤维化逆转模型 非酒精性脂肪性肝纤维化逆转模型 

分 类 号：R575.2[医药卫生—消化系统] R-332[医药卫生—内科学]