外周血SFRP4、S100A12水平与老年重症胰腺炎患者急性期预后的关系  

Relationship between levels of serum SFRP4 and S100A12 and prognosis in elderly patients with severe pancreatitis in acute phase

作　　者：张进进[1] 唐昊[1] 李冉 Zhang Jinjin;Tang Hao;Li Ran(Department of Emergency Medicine,First Affiliated Hospital of Anhui Medical University,Hefei,Anhui,230000,P.R.China)

机构地区：[1]安徽医科大学第一附属医院急诊内科,安徽合肥230000

出　　处：《老年医学与保健》2022年第5期1063-1069,共7页Geriatrics & Health Care

摘　　要：目的探讨老年重症胰腺炎患者外周血分泌型卷曲相关蛋白4(SFRP4)、S100钙结合蛋白A12(S100A12)表达水平,并分析其与患者急性期预后的关系。方法选择2017年8月—2021年10月安徽医科大学第一附属医院收治的132例老年胰腺炎患者,根据疾病程度分为重症胰腺炎组(n=80)和轻症胰腺炎组(n=52),并以同期于本院30名体检健康者作为健康对照组。于健康对照组入组当日、重症胰腺炎组和轻症胰腺炎组患者入院后第第1天、第3天、第5天、第7天采集外周血,分离血清,测定并比较3组血清SFRP4和S100A12水平差异。根据重症胰腺炎组急性期预后情况分为预后存活亚组和预后死亡亚组,比较2亚组基线资料、血清SFRP4和S100A12水平,分析血清SFRP4和S100A12水平与重症胰腺炎组患者急性期预后的关系及早期预测价值。结果重症胰腺炎组和轻症胰腺炎组血清SFRP4和S100A12水平均高于健康对照组(P<0.05);重症胰腺炎组和轻症胰腺炎组患者入院后血清SFRP4和S100A12水平变化趋势相同,以第3天水平最高,第7天水平最低(P<0.05);重症胰腺炎组各时间点血清SFRP4和S100A12水平均高于轻症胰腺炎组同时间点(P<0.05)。预后存活亚组患者入院后血清SFRP4和S100A12水平以第3天水平最高,第7天水平最低(P<0.05);预后死亡亚组患者入院后血清SFRP4和S100A12水平持续升高,以第7天最高(P<0.05);入院第1天、第3天、第5天、第7天预后死亡亚组血清SFRP4和S100A12水平均高于预后存活亚组(P<0.05)。进一步经Pearson相关性分析发现,血清SFRP4和S100A12与老年重症胰腺炎患者急性期预后呈正相关(r=0.559、0.627,P均<0.05)。多因素回归分析显示,除早期合并休克、早期合并多器官功能衰竭、入院48 h内APACHEⅡ评分、血淀粉酶外,患者血清SFRP4和S100A12也是影响老年重症胰腺炎患者急性期预后的因素。患者血清SFRP4和S100A12水平预测老年重症胰腺炎患者急性期�Objective To investigate the expression levels of serum secreted frizzled-related protein 4(SFRP4)and S100 calcium binding protein A12(S100 A12)in peripheral blood of elderly patients with severe pancreatitis,and analyze their relationship with the prognosis of patients in acute phase.Methods 132 elderly patients with pancreatitis admitted to First Affiliated Hospital of Anhui Medical University from August 2017 to October 2021 were selected.They were divided into severe pancreatitis group(n=80)and mild pancreatitis group(n=52)according to the condition of disease.30 healthy subjects who underwent physical examination in this hospital during the same period were selected as the healthy control group.The peripheral blood samples were collected from the healthy control group on the day of enrollment,and the severe pancreatitis group and mild pancreatitis group on the first,third,fifth and seventh days after admission.Serum was separated,and the levels of serum SFRP4 and S100 A12 were measured and compared among the three groups.According to the prognosis of severe pancreatitis patients in acute phase,they were divided into survival subgroup and death subgroup.The baseline data and the changes of serum SFRP4 and S100 A12 were compared between the two subgroups.The relationship between the changes of serum SFRP4 and S100 A12 and the prognosis of patients with severe pancreatitis in acute phase and their early predictive value were analyzed.Results The levels of serum SFRP4 and S100 A12 of the severe pancreatitis group and mild pancreatitis group were higher than those of the healthy control group at each time point(P<0.05).The changes of the levels of serum SFRP4 and S100 A12 in the severe pancreatitis group and mild pancreatitis group after admission showed the same trend,with the highest level on the 3 rd day and the lowest level on the 7 th day(P<0.05).The levels of serum SFRP4 and S100 A12 of the severe pancreatitis group were higher than those of the mild pancreatitis group at the same time point(P<0.05).The lev

关 键 词：老年 重症胰腺炎 分泌型卷曲相关蛋白4 S100钙结合蛋白A12 急性期预后 

分 类 号：R576[医药卫生—消化系统]