奥施康定联合帕米膦酸二钠治疗老年恶性肿瘤骨转移癌性疼痛的临床研究  

Clinical study of oxycontin combined with pamidronate disodium in the treatment of cancer pain caused by bone metastases of malignant tumors in elderly patients

作　　者：查从亮 刘勇[1] 叶军 缪振稳 蔡丰[2] Zha Congliang;Liu Yong;Ye Jun;Miao Zhenwen;Cai Feng(Department of Oncology,Tongling Municipal Hospital(Tongling Hospital Affiliated to Wannan Medical College),Tongling,Anhui,244000,P.R.China;Department of Oncology and Radiotherapy,First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,233004,P.R.China)

机构地区：[1]铜陵市立医院(皖南医学院附属铜陵医院)肿瘤科,安徽铜陵244000 [2]蚌埠医学院第一附属医院肿瘤放疗科,安徽蚌埠233004

出　　处：《老年医学与保健》2022年第5期1070-1074,共5页Geriatrics & Health Care

基　　金：蚌埠医学院科研课题(BYKY1777)。

摘　　要：目的研究基于放疗采用奥施康定联合帕米膦酸二钠治疗老年骨转移癌性疼痛的有效性与安全性。方法选取2017年6月—2022年1月铜陵市立医院收治的80例老年骨转移癌患者,采用数字表法随机分为观察组(n=40)和对照组(n=40)。对照组采用奥施康定治疗,观察组在使用奥施康定的基础上加用帕米膦酸二钠,2组均同时联合姑息性放疗。使用疼痛数字评价量表(numerical rating scale,NRS)评估并比较2组患者治疗前后疼痛程度;使用KPS(Karnofsky performance scale)功能状态评分量表评估并比较2组患者治疗前后生活质量;观察并比较2组治疗过程中不良反应。结果治疗1周和8周后,观察组疼痛缓解率和治疗前后NRS评分差异均显著高于对照组(P<0.05)。治疗8周后,观察组KPS评分明显高于对照组[(82.4±12.5)分vs(68.7±13.1)分,P<0.05],观察组的治疗满意率显著高于对照组(72.5%vs 50.0%,P<0.05)。2组治疗不良反应发生率差异无统计学意义(P>0.05)。结论基于放疗采用奥施康定联合帕米膦酸二钠治疗老年恶性肿瘤骨转移癌性疼痛,疗效确定,有助于减轻患者疼痛,提高患者生活质量,安全性好,可望成为治疗骨转移癌的有效方法。Objective To investigate the efficacy and safety of oxycontin combined with pamidronate disodium in the treatment of cancer pain caused by bone metastases of malignant tumorin elderly patientswho received radiotherapy.Methods 80 elderly patients with bone metastatic cancer admitted to Tongling Municipal Hospital from June 2017 to January 2022 were selected and randomly divided into observation group(n=40)and control group(n=40)by the number table method.The control group was treated with oxycontin,and the observation group was treated with pamidronate disodium on the basis of oxycontin.Both groups received palliative radiotherapy.The pain degree of patients in the two groups before and after treatment was evaluated with the Numerical Rating Scale(NRS)and compared between the two groups.Karnofsky Performance Scale(KPS)was used to evaluate and compare the quality of life of patients in the two groups before and after treatment.The adverse reactions during treatment were observed and compared between the two groups.Results After 1 week and 8 weeks of treatment,the pain relief rate and NRS score difference before and after treatment in the observation group were significantly larger than those in the control group(P0.05).Conclusion Based on radiotherapy,oxycontin combined with pamidronate disodium in the treatment of cancer pain caused by bone metastases of malignant tumorin elderly patients has definite efficacy,which is helpful to relieve pain of patients,improve their quality of life,and has good safety.It is expected to be an effective method for the treatment of bone metastases cancer.

关 键 词：老年 骨转移癌 癌性疼痛 奥施康定 帕米膦酸二钠 放疗 

分 类 号：R738.1[医药卫生—肿瘤]