血清五项肿瘤标志物及降钙素原水平在肺腺癌化疗前后的变化及其临床意义  

Level Changes and Clinical Significance of Serum Five Tumor Markers and Procalcitonin before and after Chemotherapy in Lung Adenocarcinoma

作　　者：徐李红 王禺[2] 岳虹[2] XU Li-hong;WANG Yu;YUE Hong(Department of Laboratory,Shaanxi Honorary Military Rehabilitation Hospital,Huayin Shaanxi 714200)

机构地区：[1]陕西省荣誉军人康复医院检验科,陕西华阴714200 [2]西安市第一医院检验科,陕西西安710002

出　　处：《医学临床研究》2022年第9期1395-1398,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清五项肿瘤标志物及降钙素原(PCT)水平在肺腺癌化疗前后的变化及其临床意义。【方法】两院收治的124例肺腺癌患者,均在常规治疗基础上联合紫杉醇(或多西紫杉醇)化疗方案,对患者血清五项肿瘤细胞标志物[癌胚抗原(CEA)、甲胎蛋白(AFP)、糖蛋白抗原19-9(CA19-9)、糖蛋白抗原125(CA-125)、糖蛋白抗原15-3(CA15-3)及PCT]进行检测,分别比较化疗有效组与无效组、治疗后2年生存组与死亡组患者化疗前后上述各项指标的变化。【结果】124例肺腺癌患者化疗后血清CEA、CA-125及PCT水平较化疗前均降低(P<0.05)。124例患者中治疗有效患者74例(59.68%),化疗无效患者50例(40.32%),两组化疗后血清CEA、CA-125水平均低于化疗前,且有效组化疗后血清PCT水平低于化疗前(P<0.05);有效组化疗后血清CEA、CA-125、PCT水平均低于无效组(P<0.05)。124例肺腺癌患者中生存周期≥2年者28例(22.58%),96例(77.42%)患者在2年内死亡,生存组及死亡组化疗后血清CEA、CA-125及PCT水平均低于化疗前,且生存组均低于死亡组(P<0.05)。生存组化疗后血清CEA、CA-125及PCT水平降低比例均高于死亡组(P<0.05)。【结论】血清CEA、CA-125及PCT水平变化与肺腺癌患者的疗效、预后关系密切,可用于辅助评估肺腺癌患者的病情进展及预后。【Objective】To explore the changes and clinical significance of serum five tumor markers and procalcitonin(PCT)levels before and after chemotherapy for lung adenocarcinoma.【Methods】A total of 124 patients with lung adenocarcinoma two were treated with paclitaxel(or docetaxel)chemotherapy on the basis of routine treatment.Five tumor cell markers in serum[carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),glycoprotein antigen 19-9(CA19-9),glycoprotein antigen 125(CA-125),glycoprotein antigen 15-3(CA15-3)]and PCT were detected.Changes of the above indicators before and after chemotherapy were compared between the chemotherapy effective group and the ineffective group,the two-year survival group and the death group.【Results】The overall analysis of patients with lung adenocarcinoma showed that the levels of serum CEA,CA-125 and PCT after treatment were lower than those before treatment(P<0.05).Among 124 patients with lung adenocarcinoma,74 patients(59.68%)were effective in treatment,and 50 patients(40.32%)were ineffective in chemotherapy.The serum CEA and CA-125 levels in the two groups after treatment were lower than those before treatment,and the serum PCT levels in the chemotherapy effective group after treatment were lower than those before treatment(P<0.05).After treatment,serum CEA,CA-125 and PCT levels in the effective group were lower than those in the ineffective group(P<0.05).Among 124 patients with lung adenocarcinoma,28 patients(22.58%)had a survival period of≥2 years,and 96 patients(77.42%)died within 2 years.The levels of serum CEA,CA-125 and PCT in the two groups after treatment were lower than those before treatment,and those in the survival group were lower than in the death group(P<0.05).The rates of serum CEA,CA-125 and PCT level decrease in the survival group after chemotherapy were higher than those in the death group(P<0.05).【Conclusion】The changes of serum CEA,CA-125 and PCT levels are closely related to the curative effect and prognosis of patients with lung adenocarcinoma,wh

关 键 词：肺肿瘤 腺癌 降钙素原/血液 癌胚抗原/血液 甲胎蛋白类/血液 CA-19-9抗原/血液 CA-125抗原/血液 

分 类 号：R734.2[医药卫生—肿瘤]