基于伏邪理论探讨对菌群失调致溃疡性结肠炎发病的认识  

Explore the understanding of ulcerative colitis caused by dysbacteriosis based on the theory of latent pathogen

作　　者：陈国森 姬永宽 黄钲淇 梁锦娉 刘果 CHEN Guosen;JI Yongkuan;HUANG Zhengqi;LIANG Jinping;LIU Guo(Teaching and Research Section of Wen Disease,College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing,102401,China)

机构地区：[1]北京中医药大学中医学院温病教研室,北京102401

出　　处：《中国中西医结合消化杂志》2022年第10期743-746,752,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家自然科学基金(No:81873214);国家中医药管理局中医药创新团队及人才支持计划项目-中医疫病学传承创新团队(No:ZYYCXTD-C-202006);北京中医药大学基本科研业务费项目(No:2020-JYB-ZDGG-012)。

摘　　要：随着历代医家对伏邪理论的完善和发展,伏邪理论的运用已不再局限于温病学范畴,而是被广泛应用到各种疑难杂症中。肠道菌群是近年来的研究热点,菌群失调与溃疡性结肠炎发病的关系已得到证实。溃疡性结肠炎反复发作,缠绵难愈,无论活动期或缓解期均存在肠道菌群的失调,与伏邪致病之正虚失手、伏邪内生、留而不去、反复发作的特点相似,故可用伏邪理论解释其机制。该文从伏邪理论探讨对菌群失调致溃疡性结肠炎发病的认识,为临床提供新的见解与治疗思路。With the improvement and development of the theory of latent pathogen by doctors in previous dynasties,the application of the theory of latent pathogen is no longer limited to the category of febrile diseases,but is widely used in various difficult and miscellaneous diseases.Intestinal flora is a research hotspot in recent years.The relationship between flora imbalance and ulcerative colitis has been confirmed.Ulcerative colitis occurs repeatedly in clinic and is lingering and difficult to heal.No matter in the active stage or remission stage,there is an imbalance of intestinal flora,which is similar to the characteristics of recurrent attacks,so the mechanism can be explained by the theory of latent pathogen.

关 键 词：伏邪 溃疡性结肠炎 肠道菌群 痢疾 休息痢 病机 

分 类 号：R574.62[医药卫生—消化系统]