Current status and prospects of hematopoietic stem cell transplantation in China  

作　　者：Xiaoqi Wang Ruihao Huang Xiaohui Zhang Xi Zhang 

机构地区：[1]Medical Center of Hematology,Xinqiao Hospital,State Key Laboratory of Trauma,Burn and Combined Injury,Army Medical University,Chongqing 400037,China [2]Peking University People’s Hospital&Peking University Institute of Hematology,National Clinical Research Center for Hematologic Disease,Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,China

出　　处：《Chinese Medical Journal》2022年第12期1394-1403,共10页中华医学杂志（英文版）

基　　金：This study was supported by grants from National Key Research and Development Program of China(No.2017YFA0105503);NationalNaturalScience FoundationofChina(No.82020108004);Natural Science Foundation of Chongqing Innovation Group(No.cstc2021jcyj-cxttX0001);2020 Open Project of National Clinical Research Center for Hematological Malignancies(No.2020ZKZC02).

摘　　要：Hematopoietic stem cell transplantation(HSCT)is a highly effective and unique medical procedure for the treatment of most hematological malignancies.The first allogeneic transplantation was performed by E.Donnall Thomas in 1957.Since then,the field has evolved and expanded worldwide.The first successful allogenic HSCT(allo-HSCT)in China was conducted in 1981.Although the development of allo-HSCT in China lagged,China has since made considerable contributions to the process of HSCT worldwide,with more than 10,000 HSCTs performed annually.In particular,haploid HSCT(haplo-HSCT)technology represented in the Beijing Protocol has demonstrated similar efficacy to human leukocyte antigen-matched HSCT and has gradually become the pre-dominant choice for allo-HSCT in China.Currently,the number of haplo-HSCT procedures exceeds 5000 per year,and the Beijing Protocol has been greatly improved by implementing updated individualized strategies for controlling complications,relapse,and infection management.In addition,innovative haplo-HSCT technologies developed by different medical transplantation centers,such as Soochow,Zhejiang,Fujian,Chongqing,and Anhui,have emerged,providing inspiration for the refinement of global practice.This review will focus on the current activity in this field and highlight important trends that are vital in China’s allo-HSCT process,examining the current viewpoint and future directions.

关 键 词：Hematopoietic stem cell transplantation HAPLOIDENTICAL China 

分 类 号：R457.7[医药卫生—治疗学]