Relationship between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia: a meta-analysis  

作　　者：Sisi Wang Chuyang Lin Tingting Xi Yu Tong Jinlin Wu 

机构地区：[1]Department of Pediatrics,Key Laboratory of Birth Defects and Related Disease of Women and Children,Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Oncology and Translational Medicine》2022年第5期217-225,共9页肿瘤学与转化医学（英文版）

基　　金：Supported by the National Key Project of Neonatal Children (No. 1311200003303);Grants from the Science and Technology Bureau of Sichuan Province (No. 2021YJ0211 to Jinlin Wu);Grants from the Health Planning Committee of Sichuan Province (No. 20PJ070 to Jinlin Wu)

摘　　要：Objective The aim of the study was to systematically evaluate the correlation between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia.Methods Computer databases including PubMed,EMBASE,and Web of Science were searched for case-control studies on the association between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia.The retrieval period was from the establishment of the database to November 2020.Two researchers independently screened the literature,extracted the data,evaluated the risk of bias in the included studies,and used Stata 14.0 software for meta-analysis.Results A total of 48 case-control studies were included,with 10520 and 44049 cases in the case and control groups,respectively.The meta-analysis results showed that rs4132061 and rs11978267 of IKZF1 were significantly correlated with the risk of acute lymphoblastic leukemia(ALL).Conclusion Current evidence indicates that rs4132061 and rs11978267 of IKZF1 are significantly associated with the risk of B-cell ALL.

关 键 词：IKZF1 gene polymorphism acute lymphoblastic leukemia(ALL) META-ANALYSIS systematic reviews case-control study 

分 类 号：R733.71[医药卫生—肿瘤]