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作 者:吴迪 WU Di(General Hospital of Fuxin Mining Group,Liaoning Health Industry Group,Fuxin 123000,China)
机构地区:[1]辽宁省健康产业集团阜新矿总医院,123000
出 处:《中国实用医药》2022年第21期135-137,共3页China Practical Medicine
摘 要:目的研究不同剂量奥美拉唑治疗消化性溃疡合并上消化道出血的临床效果。方法98例消化性溃疡合并上消化道出血患者,随机分为对照组和研究组,每组49例。对照组采用常规剂量奥美拉唑治疗,研究组采用大剂量奥美拉唑治疗。比较两组患者临床治疗效果以及治疗后溃疡愈合情况。结果对照组治疗显效20例(40.82%),有效18例(36.73%),无效11例(22.45%),治疗总有效率为77.55%;研究组治疗显效37例(75.51%),有效9例(18.37%),无效3例(6.12%),治疗总有效率为93.88%。研究组治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,对照组溃疡愈合17例(34.69%),好转20例(40.82%),无效12例(24.49%),溃疡愈合总有效率为75.51%;研究组溃疡愈合30例(61.22%),好转15例(30.61%),无效4例(8.16%),溃疡愈合总有效率为91.84%。研究组溃疡愈合总有效率高于对照组,差异具有统计学意义(P<0.05)。结论针对消化性溃疡合并上消化道出血的患者,为进一步提高患者的治疗效果,促进患者溃疡愈合,建议选择大剂量奥美拉唑治疗。Objective To study the clinical effect of different doses of omeprazole in the treatment of peptic ulcer combined with upper gastrointestinal bleeding.Methods A total of 98 patients with peptic ulcer complicated with upper gastrointestinal bleeding were randomly divided into control group and research group,with 49 cases in each group.The control group was treated with conventional-dose omeprazole,and the research group was treated with high-dose omeprazole.The clinical effect and ulcer healing after treatment were compared between the two groups.Results After treatment,in the control group,20 cases(40.82%)were markedly effective,18 cases(36.73%)were effective,and 11 cases(22.45%)were ineffective,with a total effective rate of 77.55%;in the research group,37 cases(75.51%)were markedly effective,9 cases(18.37%)were effective,and 3 cases(6.12%)were ineffective,with a total effective rate of 93.88%.The total effective rate of treatment in the research group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,in the control group,there were 17 cases(34.69%)of ulcer healing,20 cases(40.82%)of ulcer improvement,12 cases(24.49%)of no effect,and the total effective rate of ulcer healing was 75.51%;in the research group,there were 30 cases(61.22%)of ulcer healing,15 cases(30.61%)of ulcer improvement,4 cases(8.16%)of no effect,and the total effective rate of ulcer healing was 91.84%.The total effective rate of ulcer healing in the research group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with peptic ulcer combined with upper gastrointestinal bleeding,it is recommended to choose high-dose omeprazole for treatment to further improve the therapeutic effect of patients and promote the healing of ulcers.
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