中医体质类型与慢性萎缩性胃炎相关性研究的系统评价与Meta分析  

Correlation Between TCM Constitution Types and Chronic Atrophic Gastritis:A Systematic Review and Meta-analysis

作　　者：王雨 赵薇巍 姚玉璞[1] 彭丹[1] 杨志然 陈润花[1] WANG Yu;ZHAO Wei-wei;YAO Yu-pu;PENG Dan;YANG Zhi-ran;CHEN Run-hua(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078)

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《世界中西医结合杂志》2022年第9期1715-1722,共8页World Journal of Integrated Traditional and Western Medicine

基　　金：北京中医药大学“名医培育计划”(京中校发[2018]98号)。

摘　　要：目的基于文献探究中医体质类型分布与慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)的相关性与规律性,为中医药防治慢性萎缩性胃炎提供循证医学证据。方法检索中国知网数据库(CNKI)、重庆维普中文科技期刊数据库(VIP)、万方数据(Wanfang Database)、中国生物医学文献数据库(CBM)、PubMed、Cochrane Library、Embase、Webof Science 8个数据库,纳入所有评价中医体质类型与慢性萎缩性胃炎相关性的临床研究文献。采用R语言(version 4.0.5)与Review Manager 5.4进行Meta分析,以随机效应模型合并数据,运用漏斗图、Egger′s test、Begg′s test评估偏倚风险。结果共18项研究符合纳入标准,样本量总计3172例。气虚质、阳虚质和阴虚质占慢性萎缩性胃炎患者的比例分别为18%[95%CI(13%,23%),Q=221.84,P<0.01]、17%[95%CI(13%,24%),Q=278.14,P<0.01]、16%[95%CI(12%,20%),Q=138.08,P<0.01]。华东地区与华北地区阳虚质比例相当,华东地区气虚质较多,华北地区阴虚质较多。女性气虚质、气郁质比例高于男性,而男性湿热质、痰湿质比例高于女性。痰湿质在伴有幽门螺杆菌感染的CAG患者中分布较多。轻中度萎缩性胃炎患者气虚质、阳虚质、湿热质较多,而重度萎缩性胃炎患者阳虚质、阴虚质、血瘀质较多。结论气虚质、阳虚质和阴虚质是慢性萎缩性胃炎患者的主要体质类型,也是导致慢性萎缩性胃炎发病的重要危险因素。Objective To explore the correlation and regularity between the distribution of traditional Chinese medicine(TCM)constitution types and chronic atrophic gastritis(CAG)based on literature review,and provide evidence-based medical evidence for the prevention and treatment of CAG with TCM.Methods All the clinical studies related to the evaluation of TCM constitution types and CAG were included from China National Knowledge Infrastructure(CNKI),VIP Chinese Technology Periodical Database,Wanfang Database,China Biology Medicine disc(CBMdisc),PubMed,Cohrane Library,Embase,and Web of Science.Meta-analysis was performed using R language(version 4.0.5)and Review Manager 5.4.A random effect model was used to merge data,and the funnel plot,Egger′s test,and Begg′s test were used to evaluate the risk of bias.Results Eighteen studies met the inclusion criteria,with 3172 samples.The proportions of qi-deficiency,yang-deficiency,and yin-deficiency constitutions in patients with CAG were 18%[95%CI(13%,23%),Q=221.84,P<0.01],17%[95%CI(13%,24%),Q=278.14,P<0.01],16%[95%CI(12%,20%),Q=138.08,P<0.01],respectively.The proportion of the yang-deficiency constitutions in East China was similar to that in North China.There were more qi-deficiency constitutions in East China and more yin-deficiency constitutions in North China.The proportion of qi-deficiency and qi-stagnation constitutions in women was higher than that in men,whereas the proportion of damp-heat and phlegm-dampness constitutions in men was higher than that in women.The phlegm-dampness constitutions were commonly distributed in patients with CAG combined with Helicobacter pylori(Hp)infection.Most patients with mild and moderate atrophic gastritis had qi-deficiency,yang-deficiency,and damp-heat constitutions.Most patients with severe atrophic gastritis had yang-deficiency,yin-deficiency,and blood-stasis constitutions.Conclusion Qi-deficiency,yang-deficiency,and yin-deficiency constitutions are the main constitution types of patients with CAG,and they are also important risk fa

关 键 词：中医体质 慢性萎缩性胃炎 相关性 系统评价 META分析 

分 类 号：R573.32[医药卫生—消化系统]