乳康饮对乳腺癌患者αβT和γδT细胞的调控及生活质量的影响  

Rukangyin Regulates αβT and γδT Cells and Quality of Life in Patients with Breast Cancer

作　　者：孟令国 魏昌然 王莹 李湘奇 MENG Ling-guo;WEI Chang-ran;WANG Ying;LI Xiang-qi(Clinical Laboratory,The Second Affiliated Hospital of Shandong First Medical University,Tai′an Shandong 271000;Graduate School,Shandong University of Traditional Chinese Medicine,Jinan Shandong 250014;Department of Reha-bilitation,The Second Affiliated Hospital of Shandong First Medical University,Tai′an Shandong 271000;Department of Breast Surgery,The Second Affiliated Hospital of Shandong First Medical University,Tai′an Shandong 271000)

机构地区：[1]山东第一医科大学第二附属医院检验科,山东泰安271000 [2]山东中医药大学研究生院,山东济南250014 [3]山东第一医科大学第二附属医院康复医学科,山东泰安271000 [4]山东第一医科大学第二附属医院乳腺外科,山东泰安271000

出　　处：《世界中西医结合杂志》2022年第8期1634-1639,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(81473687);山东省自然科学基金(ZR2020MH357);山东省中医药科技发展计划(2017-260);泰山医学院高层次课题培育计划(2018GCC14);山东第一医科大学学术提升计划(2019QL017)。

摘　　要：目的观察乳康饮对乳腺癌化疗患者αβT、γδT细胞和生活质量的影响,探讨中药调控细胞免疫提高生活质量的作用。方法选取2019年1月—2019年12月期间山东第一医科大学第二附属医院乳腺外科收治的乳腺癌化疗患者128例,抽签法随机分为观察组86例,对照组42例,所有患者采用AC-T方案化疗8个周期。观察组化疗同步给予乳康饮冲服,1剂/d,连服10 d。检测化疗前、后外周血αβT、γδT细胞,Karnofsky评分及PSQI指数的变化。结果两组患者化疗前后αβT、γδT细胞均有不同程度的改变,但观察组化疗前后比较,差异无统计学意义(P>0.05),对照组化疗后CD3^(+)、CD4^(+)、γδT细胞较化疗前下降,差异有统计学意义(P<0.05);化疗后对照组CD3^(+)、γδT细胞较观察组下降,差异有统计学意义(P<0.05)。化疗后两组患者karnofasky(卡式,KPS)评分及匹兹堡睡眠质量指数(Pittsbuigh Sleep Quality Indes,PSQI)的7个维度化疗前后均出现变化,观察组化疗后PSQI的睡眠质量、睡眠时间、睡眠障碍3个维度评分较治疗前升高,差异有统计学意义(P<0.05);对照组化疗后睡眠质量、睡眠时间、入睡时间、睡眠效率、催眠药物、睡眠障碍、日间功能7个维度评分较治疗前升高,差异均有统计学意义(P<0.05,P<0.01);化疗后对照组与观察组比较,睡眠时间、入睡时间、睡眠效率、催眠药物、睡眠障碍5个维度的评分升高,差异有统计学意义(P<0.01),睡眠质量、日间功能2个维度的评分升高,但差异无统计学意义(P>0.05)。观察组化疗前后KPS评分比较,差异无统计学意义(P>0.05),对照组化疗后KPS评分较化疗前下降,差异有统计学意义(P<0.01),对照组化疗后KPS评分较观察组下降,差异有统计学意义(P<0.05)。结论乳康饮显著拮抗化疗对乳腺癌患者部分αβT细胞和γδΤ细胞的损害,改善患者体质和睡眠,提高患者的生活质量。Objective To observe the effect of Rukangyin on αβT and γδT cells and quality of life in patients with breast cancer undergoing chemotherapy,and to explore the role of Chinese medicine in regulating cellular immunity and improving quality of life.Methods A total of 128 patients with breast cancer treated with chemotherapy from January to December in 2019 were randomly assigned into an observation group(86 patients)and a control group(42 patients).All the patients were treated with AC-T chemotherapy regimen for 8 cycles.The observation group was additionally treated with Rukangyin at the same time at one dose a day for 10 days.The levels of peripheral blood αβT and γδT cells,Karnofsky score,and Pittsburgh sleep quality index(PSQI)were determined before and after chemotherapy.Results The levels of αβT and γδT cells in both groups changed after chemotherapy,whereas they showed no statistical differences in the observation group(P>0.05).The CD3^(+),CD4^(+),and γδT cell counts in the control group decreased after chemotherapy compared with those before chemotherapy(P<0.05).After chemotherapy,the levels of CD3^(+)andγδT cells in the control group were lower than those in the observation group(P<0.05).The KPS score and the scores of seven PSQI components changed after chemotherapy in the two groups.In the observation group,the scores for sleep quality,sleep duration,and sleep disturbance increased after chemotherapy(P<0.05).In the control group,the scores of all the seven PSQI indicators(sleep quality,sleep duration,sleep latency,sleep efficiency,use of sleep medication,sleep disturbance,and daytime dysfunction)increased after chemotherapy(P<0.05 or P<0.01).After chemotherapy,the scores of sleep duration,sleep latency,sleep efficiency,use of sleep medication,and sleep disturbancein the control group were higher than those in the observation group(P<0.01).The KPS score of the control group decreased after chemotherapy(P<0.01),while it showed no significant difference in the observation group(P>0.05).Moreo

关 键 词：乳康饮 乳腺癌 ΑΒT细胞 ΓΔT细胞 生活质量 

分 类 号：R737.9[医药卫生—肿瘤]