热疗联合动脉灌注化疗栓塞对局部复发鼻咽癌的临床应用价值  

The clinical application value of hyperthermia combined with arterial infusion chemoembolization in treating local recurrence of nasopharyngeal carcinoma

作　　者：邢辉 徐舒 XING Hui;XU Shu(Department of Oneology Jinshahou Hospial Guanghou Uninersity of Tradional Chinese Medicine Guanghou Guangdong Province 510168,China)

机构地区：[1]广州中医药大学金沙洲医院肿瘤科,510168 [2]中国科学院大学深圳医院肿瘤科

出　　处：《介入放射学杂志》2022年第9期898-901,共4页Journal of Interventional Radiology

摘　　要：目的 评价热疗联合区域性动脉灌注化疗栓塞对局部复发鼻咽癌的临床应用价值。方法 回顾性分析60例局部复发鼻咽癌患者行热疗联合区域性动脉灌注化疗或配合栓塞治疗的临床资料。观察疾病缓解率(ORR)、生活质量状况(KPS评分)和疾病无进展生存期(PFS)。结果 治疗后临床症状改善或肿瘤溃缩开始时间为24~96 h,平均48 h。总ORR为83.3%,平均PFS为7个月。生活质量评分提升10分35例,20分7例,无变化18例。结论 热疗联合选择性区域性动脉灌注化疗及栓塞对局部复发鼻咽癌具有较高的局部控制率,对生活质量提升作用明确,延长了疾病无进展生存期。Objective To evaluate the clinical value of hyperthermia combined with regional arterial infusion chemoembolization in treating local recurrence of nasopharyngeal carcinoma. Methods The clinical data of 60 patients with local recurrence of nasopharyngeal carcinoma, who received hyperthermia combined with regional arterial infusion chemotherapy or embolization treatment, were retrospectively analyzed. The objective remission rate(ORR) of tumor, quality of life status(KPS score), and progression-free survival(PFS)were recorded. Results Within 24-96 hours(mean of 48 hours) after treatment, the clinical symptoms began to improve and/or the tumor began to shrink. The total ORR was 83.3%, the mean PFS was 7 months. The KPS score was increased by 10 points in 35 patients and by 20 points in 7 patients;and in 18 patients the KPS score was unchanged. Conclusion For local recurrence of nasopharyngeal carcinoma, hyperthermia combined with selective regional arterial infusion chemotherapy and embolization has higher local control rate of tumors, and it can remarkably improve the quality of life and prolong PFS.(J Intervent Radiol, 2022,31: 898-901)

关 键 词：热疗 区域性动脉灌注化疗、栓塞 局部复发鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]