m^(6)A RNA甲基化修饰与肿瘤干细胞关系的研究进展  

Research advances in relationship between m^(6)A RNA methylation modification and cancer stem cells

作　　者：刘莲莲 何倩婷[1] LIU Lianlian;HE Qianting(Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital,Sun Yat-Sen University,Guangdong Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院口腔颌面外科,广东广州510080

出　　处：《现代肿瘤医学》2022年第21期3982-3985,共4页Journal of Modern Oncology

基　　金：国家自然科学基金青年项目(编号:82002871)。

摘　　要：N6-甲基腺苷(N^(6)-methyladeno sine,m^(6)A)作为一种可逆的转录后修饰,是真核生物mRNA中最为普遍的一种RNA修饰形式。肿瘤干细胞(cancer stem cell,CSC)是肿瘤中一群具有自我更新能力和分化潜能的细胞,在肿瘤复发、转移中起关键作用。近年来大量研究表明m^(6)A具有调节肿瘤干细胞干性的能力。本文对m^(6)A相关酶的特征及其对肿瘤干细胞的作用机制进行综述,为选择性消除肿瘤干细胞提供新的靶点及研究方向。As a reversible post-transcriptional modification,N^(6)-methyladeno sine is the most common form of RNA modification in eukaryotic mRNA.Cancer stem cells are a group of cells with self-renewal ability and differentiation potential,which play a key role in tumor recurrence and metastasis.In recent years,a large number of studies have shown that m^(6)A has the ability to regulate the stemness of cancer stem cells.This paper summaries the characteristics of m^(6)A-related enzymes and related mechanism of regulating cancer stem cells,provides new targets and research directions for the selective elimination of cancer stem cells.

关 键 词：m^(6)A修饰 肿瘤干细胞 转移 自我更新 

分 类 号：R730.5[医药卫生—肿瘤]