结膜松弛症患者睡眠、情志障碍与眼表状态的相关性  

Correlation between sleep and emotional disorders and ocular surface status in patients with conjunctival laxa

作　　者：刘江 文杭 沙咏怡 张薇[1] 项敏泓[1] LIU Jiang;WEN Hang;SHA Yongyi;ZHANG Wei;XIANG Minhong(Department of Ophthalmology,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai200062,China;Department of Ophthalmology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai200212,China)

机构地区：[1]上海中医药大学附属普陀医院眼科,上海200062 [2]上海中医药大学附属曙光医院眼科,上海200212

出　　处：《中国医药导报》2022年第30期100-103,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(82074495);上海市卫生和计划生育委员会科研课题(201840196);上海中医药大学预算内项目(2020LK068)。

摘　　要：目的观察结膜松弛症患者的睡眠和情志状态,并分析其与眼表症状的相关性。方法收集2020年10月至2021年5月上海中医药大学附属普陀医院(以下简称“我院”)眼科就诊的结膜松弛症患者46例为结膜松弛症组,另选取同期我院体检健康者27名作为正常对照组。采用匹兹堡睡眠质量指数(PSQI)评估两组睡眠状况,患者健康问卷(PHQ-9)和一般焦虑症量表(GAD-7)评估两组抑郁和焦虑状态。同时对两组进行眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、基础泪液分泌试验Ⅰ试验(SⅠT)和角膜荧光素染色(FL)检查,进一步分析结膜松弛症患者睡眠、情志障碍与眼表状态的相关性。结果结膜松弛症组PSQI、OSDI及PHQ-9、GAD-7、角膜FL评分均高于正常对照组,SⅠT、BUT低于正常对照组,差异有统计学意义(P<0.05)。相关性分析结果显示,结膜松弛症患者的PSQI、PHQ-9及GAD-7评分与OSDI呈正相关(rs>0,P<0.05),与BUT、SⅠT呈负相关(rs<0,P<0.05)。结论结膜松弛症患者睡眠质量较差,有抑郁情绪并伴眼表泪液学异常,因此在局部治疗的同时应重视睡眠和情感的综合管理,严重抑郁及焦虑患者应寻求专科治疗。Objective To observe the sleep and emotional state of patients with conjunctival laxa and analyze its correlation with and ocular surface symptoms.Methods A total of 46 patients with conjunctival laxa admitted to the Department of Ophthalmology,Putuo Hospital,Shanghai University of Traditional Chinese Medicine(hereinafter referred to as“our hospital”)from October 2020 to May 2021 were collected as the conjunctival laxa group,and 27 healthy people who underwent physical examination during the same period in our hospital were selected as the normal control group.Pittsburgh sleep quality index(PSQI)was used to evaluate the sleep status of the two groups.Patient health questionnaire(PHQ-9)and general anxiety disorder scale(GAD-7)were used to evaluate the depression and anxiety status of the two groups.At the same time,the ocular surface disease index(OSDI),tear film rupture time(BUT),SchirmerⅠtest(SⅠT),and corneal fluorescein staining(FL)were examined in the two groups to further analyze the correlation between sleep and emotional disorders and ocular surface status in patients with conjunctival laxa.Results The PSQI and the scores of PHQ-9,GAD-7,corneal FL in the conjunctival laxa group were higher than those in the normal control group,and SⅠT and BUT were lower than those in the normal control group,and the differences were statistically significant(P<0.05).The results of correlation analysis showed that PSQI and the scores of PHQ-9 and GAD-7 were positively correlated with OSDI(rs>0,P<0.05),and negatively correlated with BUT and SⅠT(rs<0,P<0.05).Conclusion Patients with conjunctival laxa have poor sleep quality,depression,and ocular surface lacrimal abnormalities.Therefore,comprehensive management of sleep and emotion should be paid attention to while local treatment,and specialized treatment should be sought for patients with severe depression and anxiety.

关 键 词：结膜松弛症 睡眠质量 抑郁 焦虑 眼表状态 

分 类 号：R777.3[医药卫生—眼科]