铁死亡在肿瘤浸润淋巴细胞中的作用研究进展  

Research progress of ferroptosis function in the tumor-infiltrating lymphocyte

作　　者：王榕林 马珮翔 花蕾 杨成 郭永东 李俊强 苏海川 WANG Ronglin;MA Peixiang;HUA Lei;YANG Cheng;GUO Yongdong;LI Junqiang;SU Haichuan(Department of Oncology,Tangdu Hospital,Air Force Medical University,Shaanxi Province,Xi’an710038,China)

机构地区：[1]空军军医大学唐都医院肿瘤科,陕西西安710038

出　　处：《中国医药导报》2022年第28期50-53,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81372255、81902523);吴阶平医学基金会临床科研专项资助项目(320.6750.2020-12-53)。

摘　　要：铁死亡是一种铁依赖的脂质过氧化物累积诱导的新型细胞死亡方式,其参与肿瘤的发生及进展过程。肿瘤浸润淋巴细胞是肿瘤微环境的重要组成部分。通过调节机体免疫反应,肿瘤浸润淋巴细胞调控肿瘤进展,影响肿瘤免疫治疗效果。既往研究提示铁死亡通过影响肿瘤免疫浸润淋巴细胞功能影响肿瘤进展。本综述介绍了铁死亡发生机制,并总结铁死亡在肿瘤免疫细胞中的调节功能,旨在为增敏肿瘤免疫治疗提供新策略。Ferroptosis is a novel kind of cell death which is induced by the accumulation of iron-dependent lipid peroxidation.It has been proved ferroptosis modulates the tumorigenesis and tumor progression.Tumor infiltrating immune cells are critical components of tumor microenvironment.By modulating immune response,tumor infiltrating immune cells regulate tumor development and affect immunotherapy response.Previous studies indicate ferroptosis affects tumor infiltrating immune cell function to modulate tumor progression.This review introduces the molecular mechanism of ferroptosis and summarizes the regulatory role of ferroptosis in tumor infiltrating immune cells,which is expected to provide new strategy to improve immunotherapy efficacy.

关 键 词：铁死亡 肿瘤浸润淋巴细胞 肿瘤进展 发病机制 免疫微环境 免疫治疗 

分 类 号：R735[医药卫生—肿瘤]