中药有效成分通过Wnt/β-catenin信号通路抗肝癌作用的研究进展  

Anti-hepatoma Effect of Active Ingredients of Chinese Medicine via Wnt/β-catenin Signaling Pathway:A Review

作　　者：赵永华 张玉峰[2] 樊亚芳 李楠楠[1] 刘玲芳 ZHAO Yonghua;ZHANG Yufeng;FAN Yafang;LI Nannan;LIU Lingfang(The Second Clinical Medical School of Henan University of Chinese Medicine,Zhengzhou 450002,China;The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南中医药大学第二临床医学院,郑州450002 [2]河南中医药大学第二附属医院,郑州450002

出　　处：《中国实验方剂学杂志》2022年第21期276-282,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省教育厅科技攻关计划项目(192102310428);河南省教育厅高等学校重点科研项目(19A360016);河南省中医管理局中医药文化与管理研究项目(TCM2018014)。

摘　　要：肝癌作为全球范围内最常见的消化系统恶性肿瘤之一,是导致癌症相关死亡事件发生的主要因素之一,并且发病率有逐年上升趋势,严重威胁人类健康。目前临床中主要通过手术切除、肝移植、放射和药物治疗肝癌,但在治疗的同时会产生一定的不良反应且存在高复发率与低生存率问题。中药在提高治疗肝癌综合疗效、减少不良反应方面具有独特优势,其含有的多种有效成分可通过多种靶点诱导肝癌细胞凋亡、抑制肝癌细胞增殖、迁移和逆转多药耐药等发挥抗肝癌作用,已成为防治肝癌的重要手段和抗肝癌药物的丰富研发资源。Wnt/β-连环蛋白(Wnt/β-catenin)信号通路是癌症中最经典的通路之一,其参与肿瘤细胞的增殖、细胞周期运行、迁移侵袭及肿瘤组织血管生成等过程,近年来许多研究报道中药有效成分可通过该通路发挥抗肝癌作用。因此该文总结近年来国内外文献,分析Wnt/β-catenin信号通路与肝癌发生发展具体机制间的关系,梳理黄酮类、萜类、生物碱类、多糖类及其他中药有效成分通过Wnt/β-catenin信号通路发挥诱导肝癌细胞凋亡、调节细胞周期运行、抑制肝癌细胞侵袭转移等作用的研究文献,分析并总结相关中药有效成分抗肝癌的研究进展,探讨中药有效成分通过Wnt/β-catenin信号通路发挥抗肝癌作用的具体机制,为进一步利用中药有效成分研发抗肝癌药物提供理论参考。Hepatoma is one of the most common malignant tumors of digestive system worldwide,and a main factor leading to cancer-related deaths.Its incidence is increasing year by year,posing a serious threat to human health.Currently,hepatoma is mainly treated by surgical resection,liver transplantation,radiation and drugs,but there are certain adverse reactions and problems of high recurrence rate and low survival rate.Chinese medicine has unique advantages in improving the comprehensive curative effect of hepatoma and reducing adverse reactions.With a variety of active ingredients,Chinese medicine can induce hepatoma cell apoptosis,inhibit the proliferation,migration and reverse multidrug resistance through multiple targets,thus exerting antihepatoma effect.It has become an important means for the prevention and treatment of hepatoma as well as a rich resource for anti-hepatoma drug research and development.Wnt/β-catenin signaling pathway,one of the most classical pathways in cancer,is involved in tumor cell proliferation,cell cycle,migration,invasion and tumor angiogenesis.Recently,many studies have reported that the active ingredients of Chinese medicine can play an anti-hepatoma role through this pathway.Therefore,this paper summarized the domestic and foreign literature in recent years,analyzed the relationship between wnt/β-catenin signaling pathway and the specific mechanism of hepatoma occurrence and development,and combed the literature on the effect of flavonoids,terpenoids,alkaloids,polysaccharides and other active ingredients of Chinese medicine on inducing hepatoma cell apoptosis,regulating cell cycle and inhibiting the invasion and metastasis through Wnt/β-catenin signaling pathway.In addition,the paper summarized the research progress of relevant active ingredients of Chinese medicine against hepatoma,to explore their specific mechanism against hepatoma through Wnt/β-catenin signaling pathway,so as to provide theoretical reference for further development of anti-hepatoma drugs.

关 键 词：中药 有效成分 肝癌 Wnt/β-连环蛋白(Wnt/β-catenin)信号通路 研究进展 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R2-031R285.5