光电脉搏波分析在评估动脉硬化中的价值研究  

Study on value of photoelectric pulse wave analysis in evaluating arteriosclerosis

作　　者：麦麦提·如则 阿布都艾尼·库吐鲁克[2] 帕尔哈提·吐尔逊[3] 李秀芬[3] 比拉里·艾山[3] 严传波[2] Maimaiti Ruze;Abdugheni Kutluk;Paerhati Tuerxun;LI Xiufen;Bilali Aishan;YAN Chuanbo(College of Basic Medical,Xinjiang Medical University,Urumqi 830017,China;College of Medical Engineering Technology,Xinjiang Medical University,Urumqi 830017,China;Department of Cardiology,the Affiliated Traditional Chinese MedicineHospital,Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学基础医学院,乌鲁木齐830017 [2]新疆医科大学医学工程技术学院,乌鲁木齐830017 [3]新疆医科大学附属中医医院心内科,乌鲁木齐830000

出　　处：《新疆医科大学学报》2022年第10期1122-1128,共7页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金(2017D01C178);国家自然科学基金(61201125)。

摘　　要：目的探讨光电容积脉搏波(PPG)特征参数在临床无创评估动脉硬化中的诊断价值。方法选取2019年12月—2021年10月在新疆医科大学附属中医医院心内科住院的冠心病患者38例,其中轻度动脉硬化组(19例),重度动脉硬化组(19例);另选择18例健康青年男性作为对照组。利用光电脉搏传感器采集各组的脉搏信号,基于LabVIEW平台开发的脉搏信号分析系统提取PPG特征参数:脉图面积(K)、上升时间(CT)、峰峰时间(PPT)、反射指数(RI)。对各组的PPG特征参数和颈动脉内膜中层厚度(IMT)进行比较,并进行相关性分析,绘制ROC曲线分析特征参数K、CT、PPT、RI对动脉硬化的诊断价值。结果特征参数K、CT、PPT在对照组与动脉硬化组、轻度与重度动脉硬化组间差异均有统计学意义。RI在对照组与动脉硬化组间差异有统计学意义(P<0.01)。相关分析结果显示IMT与K、CT呈正相关、与PPT呈负相关。PPG特征参数K、CT、PPT和RI诊断动脉硬化的ROC曲线下面积(AUC)分别为1、0.964、0.994、1(P<0.01),K值和RI值对动脉硬化的诊断价值最高。PPG特征参数K、CT、PPT和RI诊断动脉硬化病变程度的ROC曲线下面积(AUC)分别为0.992、0.781、0.913、0.636,、K值和PPT值对动脉硬化病变程度的诊断效果更好。结论PPG特征参数K、CT、PPT对预测动脉硬化病变程度有一定价值,可为无创评估早期动脉硬化和心血管疾病早期预测提供较好的参考依据。Objective To investigate the diagnostic value of the characteristic parameters extracted from photoplethysmography(PPG)in non-invasive assessment of atherosclerosis.Methods A total of 38 patients with coronary heart diseasehospitalized in the Department of Cardiologyfrom December 2019 to October 2021 were selected,including19 patients in the mild arteriosclerosis group and 19 patients in the severe arteriosclerosis group.Another 18 healthy young male were selected as the control group.The pulse signals of each group were collected by photoelectric pulse sensor,and the characteristic parameters of PPG were extracted based on the pulse signal analysis system developed on LabVIEW platform:pulse plot area(K),rise time(CT),peak-to-peak time(PPT),reflection index(RI).The PPG characteristic parameters and carotid linings thickness(IMT)of each group were compared,and correlation analysis was performed.ROCcurve was drawn to analyze the diagnostic value ofcharacteristic parametersK,CT,PPT,RI for arteriosclerosis.Results There were significant differences in the characteristic parameters K,CT and PPT between the control group and the arteriosclerosis group,and between the mild and severe arteriosclerosis groups.There was significant difference in RI between the control group and the arteriosclerosis group(P<0.01).The results of correlation analysis showed that IMT was positively correlated with K and CT,and negatively correlated with PPT.The area under theROCcurve(AUC)of PPG characteristic parameters K,CT,PPT and RI in the diagnosis of arteriosclerosis were 1,0.964,0.994 and 1,respectively(P<0.01).K value and RI value had the highest diagnostic value for arteriosclerosis.The area under theROCcurve(AUC)of PPG characteristic parameters K,CT,PPT and RI in diagnosing the degree of arteriosclerosis lesions were 0.992,0.781,0.913 and 0.636,respectively.The value ofK and PPT had better diagnostic effect on the degree of arteriosclerosis lesions.Conclusion PPG characteristic parameters K,CT,PPT have certain value in predicting the

关 键 词：PPG信号 特征提取 动脉硬化 无创检测 

分 类 号：R318[医药卫生—生物医学工程] TP274[医药卫生—基础医学]