开窍醒神补虚通络针刺对脑卒中后偏瘫患者平衡功能及血清NO、SOD、cGMP含量的影响  

Effect of TCM resuscitation on balance function,serum NO,SOD and cGMP levels in patients with hemiplegia after stroke

作　　者：王大斌 罗珊 刘兆丰[2] 李军 WANG Da-bin;LUO Shan;LIU Zhao-feng;LI Jun(Department of Pain,Luzhou 646000,Sichuan,China;Department of Rehabilitation,Luzhou People s Hospital,Luzhou 646000,Sichuan,China;School of Nursing,Southwest Medical University,Luzhou 646000,Sichuan,China)

机构地区：[1]泸州市人民医院疼痛科,四川泸州646000 [2]泸州市人民医院康复科,四川泸州646000 [3]泸州市人民医院西南医科大学护理学院,四川泸州646000

出　　处：《川北医学院学报》2022年第10期1344-1347,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨开窍醒神补虚通络针刺对脑卒中后偏瘫患者平衡功能及血清一氧化氮(NO)、超氧化物歧化酶(SOD)、环鸟苷酸(cGMP)含量的影响。方法:选取138例脑卒中后偏瘫患者为研究对象,根据治疗方式不同分为观察组(n=70)和对照组(n=68)。观察组患者采用开窍醒神补虚通络针刺联合常规治疗;对照组患者仅采用常规治疗,疗程均为4周。比较两组患者平衡功能[前后倾斜角(F-BIA)、左右倾斜角(L-RIA)]、血清血清细胞信使因子[环腺苷酸(cAMP)和环鸟苷酸(cGMP)]及氧化应激指标[NO、SOD和三磷酸肌醇(IP3)]、运动功能(FMA评分)及生活能力(ADL评分)、脑卒中后偏瘫中医证候严重程度。结果:治疗后,观察组患者F-BIA、L-RIA、cAMP、SOD、NO浓度及FMA评分均大于对照组(P<0.05);cGMP、IP3浓度、ADL评分及偏瘫中医证型肢体偏瘫、语言障碍、口角歪斜、吞咽困难评分均低于对照组(P<0.05)。结论:开窍醒神补虚通络针刺治疗可有效改善脑卒中后偏瘫患者的平衡能力和神经功能,提高患者的活动能力,值得临床推广应用。Objective:To explore the effect of TCM resuscitation in improving balance function of patients with hemiplegia after stroke,and its influence on serum nitric oxide(NO),superoxide dismutase(SOD)and cyclic guanosine monophosphate(cGMP)levels.Methods:A total of 138 patients with hemiplegia after stroke were selected and divided into observation group(n=70)and control group(n=68)according to different treatment methods.Patients in the observation group were given TCM resuscitation and conventional treatment,while patients in the control group were given conventional treatments only,the course of treatment was 4 weeks.The balance function[front-behind inclination angle(F-BIA),left-right inclination angle(L-RIA)],serum cellular messenger factors[cyclic adenosine monophosphate(cAMP)and cGMP],oxidative stress indexes[NO,SOD and inositol triphosphate(IP3)],motor function(FMA score),life ability(ADL score)and the severity of TCM Syndromes of hemiplegia after stroke were compared between the two groups.Results:After treatment,the F-BIA,L-RIA,cAMP,SOD,NO levels,and FMA scores of the observation group were higher than those of the control group,while the levels of cGMP and IP3,ADL scores,and the scores of TCM symptoms hemiplegia,language disorders,deviated mouth,and dysphagia in observation group were lower than those of the control group(P<0.05).Conclusion:TCM resuscitation can significantly improve the balance ability and neurological function of patients with hemiplegia after stroke,and significantly improve their activities of daily living,which is worthy of clinical promotion and application.

关 键 词：脑卒中 偏瘫 开窍醒神补虚通络针刺 一氧化氮 超氧化物歧化酶 平衡功能 生活质量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]