基于组学技术探讨微观指标在中医证研究中的价值  

Discussion on the value of microscopic indicators in the study of traditional Chinese medicine syndromes based on omics technology

作　　者：李缘缘 高碧珍[1,2,3] LI Yuan-yuan;GAO Bi-zhen(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Key Laboratory of TCM Syndrome Research in Fujian Province University,Fuzhou 350122,China;Fujian Key Laboratory of TCM Health Status,Fuzhou 350122,China)

机构地区：[1]福建中医药大学,福州350122 [2]中医证研究福建省高校重点实验室,福州350122 [3]福建省中医健康状态辨识重点实验室,福州350122

出　　处：《中华中医药杂志》2022年第10期5564-5567,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81873234,No.81273666);福建省卫生教育联合攻关计划项目(No.2019-WJ-39);福建省自然科学基金面上项目(No.2018J01875,No.2021J01891)。

摘　　要：组学技术重在“整合”的特点与中医整体观有相似之处,笔者梳理了将组学技术应用在中医证微观指标研究的现状,指出当前与组学技术相关的微观指标研究的局限。认为中医证微观指标研究的核心原则是要冲破还原论的影响,坚持和发展系统思维,并进行多组学技术联用、多种算法统计方法结合使用、共建数据共享平台、赋予微观指标中医含义,才能借助“微观指标”发展蕴含中医思维的“微观辨证”。The characteristics of omics technology focusing on ‘integration’ is similar to the holistic concept of traditional Chinese medicine(TCM). This paper summarizes the current status of the application of omics technology in the study of microscopic indicators of TCM syndromes, and points out the limitations of the current research on microscopic indicators related to omics technology. The author believes that the core principle of the research on microscopic indicators of TCM syndrome is to break through the influence of reductionism, adhere to, and develop systematic thinking. The combination of multiomics technologies, combined use of various algorithms, and statistical methods;the co-construction of a data sharing platform,with the conferring of TCM meanings on micro-indicators can help to develop ‘micro-syndrome differentiation’ containing TCM thinking with the help of ‘micro-indicators’.

关 键 词：微观指标 中医 基因组学 蛋白组学 代谢组学 代谢综合征 

分 类 号：R22[医药卫生—中医基础理论]