乳腺癌中NGX6表达与BI-RADS超声特征及淋巴结转移的关系  

Relationship of NGX6 expression with BI-RADS ultrasonographic features and lymph node metastasis in breast cancer

作　　者：刘梦涵 肖际东[1] LIU Menghan;XIAO Jidong(Department of Ultrasound,Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院超声科,长沙410013

出　　处：《临床与病理杂志》2022年第10期2427-2433,共7页Journal of Clinical and Pathological Research

基　　金：湖南省自然科学基金(2019JJ40459);湖南省卫生健康委科研课题(B2019177)。

摘　　要：目的:探讨NGX6在乳腺癌中的表达及与乳腺影像报告数据系统(breast imaging reporting and data system, BI-RADS)超声特征及淋巴结转移的关系。方法:回顾性收集162例乳腺癌的超声声像图特征及临床资料,参照BI-RADS标准予以分类。免疫组织化学法检测乳腺癌组织中NGX6的表达,分析乳腺癌组织NGX6表达与BI-RADS超声特征及淋巴结转移的关系。结果:在162例乳腺癌中,92例(56.8%)NGX6阳性表达,70例(43.2%)NGX6阴性表达。NGX6阴性表达组的乳腺癌肿块血流丰富、乳腺癌BI-RADS高类别发生率及淋巴结转移发生率均高于NGX6阳性表达组。NGX6表达与肿瘤血流程度及BI-RADS超声分类呈负相关(分别P=0.043,P=0.020,P=0.005)。结论:NGX6作为一个抑癌基因,与乳腺癌BI-RADS超声分类及超声生物学特征相关,NGX6表达水平在一定程度上可反映乳腺癌生物学行为。Objective: To investigate the relationship of NGX6 expression in breast cancer with BI-RADS ultrasonic features and lymph node metastasis. Methods: Ultrasonic features and clinical data of 162 breast cancer cases were retrospectively collected and classified according to BI-RADS criteria. The expression of NGX6 in breast cancer tissues was detected by immunohistochemistry. The relationship of NGX6 expression in breast cancer with BI-RADS ultrasonic features and lymph node metastasis was analyzed. Results: There were 92(56.8%) NGX6 positive expressions and 70(43.2%) NGX6 negative expressions in 162 breast cancers. Compared with the NGX6 positive group, the NGX6 negative group showed a higher incidence of abundant blood flow, lymph node metastasis, and higher BI-RADS ultrasound category. NGX6 expression was negatively correlated with the degree of tumor blood flow and BI-RADS ultrasound classification(P=0.043, P=0.020, P=0.005, respectively). Conclusion: NGX6, as a tumor suppressor gene, is associated with BI-RADS ultrasound classification and ultrasound biological features of breast cancer, and NGX6 expression level can reflect the biological behavior of breast cancer to some extent.

关 键 词：超声 乳腺癌 NGX6 乳腺影像报告数据系统 淋巴结转移 

分 类 号：R737.9[医药卫生—肿瘤]