MicroRNA于弥漫大B细胞淋巴瘤诊疗中的作用  

The role of microRNA in the diagnosis and treatment of diffuse large B-cell lymphoma

作　　者：张翰钰 李敬东[2] ZHANG Hanyu;LI Jingdong(The First Clinical College,Xinxiang Medical College,Henan Province,Xinxiang 453100,China;Department of Hematology,the First Affiliated Hospital of Xinxiang Medical College,Henan Province,Xinxiang 453100,China)

机构地区：[1]河南省新乡医学院第一临床学院,河南新乡453100 [2]河南省新乡医学院第一附属医院血液科,河南新乡453100

出　　处：《中国医药导报》2022年第29期38-41,49,共5页China Medical Herald

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20190434)。

摘　　要：MicroRNA(miRNA)是一类内生的、分布广泛、长度为20~24个核苷酸组成的非编码RNA,广泛存在于体液中。miRNA在恶性肿瘤中参与多种信号通路传导及靶基因的调节,在肿瘤的发生、发展、侵袭、转移中发挥重要的作用。弥漫大B细胞淋巴瘤(DLBCL)发病机制复杂,目前仍不清楚,探索miRNA在DLBCL发生发展、治疗及预后中的作用,对新药物的研发及发现预后新指标具有重要的意义。MicroRNA(miRNA)is a class of endogenous,widely distribute,and non-coding RNAs with a length of 20 to 24 nucleotides,which is widely present in body fluids.miRNA is involved in various signaling pathways and the regulation of target genes in malignant tumors,and plays an important role in the occurrence,development,invasion and metastasis of tumors.The pathogenesis of diffuse large B-cell lymphoma(DLBCL)is complex and still unclear.Exploring the role of miRNA in the development,treatment and prognosis of DLBCL is of great significance for the development of new drugs and the discovery of new prognostic indicators.

关 键 词：弥漫大B细胞淋巴瘤 MICRORNA 肿瘤微环境 预后 

分 类 号：R73[医药卫生—肿瘤]