针刺辅助氢溴酸西酞普兰治疗老年卒中后失眠伴抑郁患者的临床效果  

Clinical effect of acupuncture assisted Citalopram Hydrobromide in the treatment of elderly patients with post-stroke insomnia and depression

作　　者：周学平 曹丽娟 颜平康 ZHOU Xueping;CAO Lijuan;YAN Pingkang(Department of Geriatrics,Jinhua Second Hospital,Zhejiang Province,Jinhua 321016,China)

机构地区：[1]浙江省金华市第二医院老年科,浙江金华321016

出　　处：《中国医药导报》2022年第29期90-93,共4页China Medical Herald

基　　金：浙江省医药卫生科技计划项目(2018KY806)。

摘　　要：目的探究针刺辅助氢溴酸西酞普兰治疗老年卒中后失眠伴抑郁患者的临床效果。方法选取浙江省金华市第二医院2019年5月至2021年6月接诊的78例卒中后失眠伴抑郁的老年患者,采用随机数字表法将其分为对照组(氢溴酸西酞普兰片)和试验组(针刺辅助氢溴酸西酞普兰片),各39例。连续治疗4周后,对两组进行疗效评价,统计治疗前后两组抑郁等级、睡眠质量及血清学指标,记录两组不良反应发生情况。结果试验组疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组汉密顿抑郁量表评分、匹兹堡睡眠质量指数低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组5-羟色胺、脑源性神经营养因子水平高于治疗前,且试验组高于对照组,差异有统计学意义(P<0.05)。两组治疗期间不良反应总发生率比较,差异无统计学意义(P>0.05)。结论针刺辅助氢溴酸西酞普兰治疗老年卒中后失眠伴抑郁患者的效果确切,可以改善患者睡眠障碍与抑郁倾向,安全性较好,可以应用于临床。Objective To explore the clinical effect of acupuncture assisted Citalopram Hydrobromide in the treatment of elderly patients with post-stroke insomnia and depression.Methods A total of 78 elderly patients with post-stroke insomnia and depression admitted to Jinhua Second Hospital,Zhejiang Province from May 2019 to June 2021 were selected and divided into control group(Citalopram Hydrobromide Tablets)and experimental group(acupuncture assisted Citalopram Hydrobromide Tablets)by random number table method,with 39 cases in each group.After continuous treatment for four weeks,the efficacy of the two groups was evaluated.The depression grade,sleep quality,and serological indexes of the two groups before and after treatment were counted,and the incidence of adverse reactions in the two groups was recorded.Results The efficacy of the experimental group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of Hamilton depression scale and Pittsburgh sleep quality index in the two groups were lower than those before treatment,and the experimental group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of 5-hydroxytryptamine and brain-derived neurotrophic factor in the two groups were higher than those before treatment,and the experimental group was higher than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Acupuncture assisted Citalopram Hydrobromate has a definite effect on elderly patients with insomnia and depression after stroke,which can improve the sleep disorder and depression tendency of patients,with good safety,and can be applied in clinical practice.

关 键 词：针刺 氢溴酸西酞普兰 卒中 失眠 抑郁 

分 类 号：R74[医药卫生—神经病学与精神病学]