奥扎格雷钠治疗脑血栓形成的临床效果研究  

Study on clinical effect of ozagrel sodium in the treatment of cerebral thrombosis

作　　者：玄鸿霞 XUAN Hong-xia(Hongda Hospital of Jiamusi University,Jiamusi 154002,China)

机构地区：[1]佳木斯大学宏大医院,154002

出　　处：《中国实用医药》2022年第22期19-22,共4页China Practical Medicine

摘　　要：目的分析在脑血栓形成治疗中采用奥扎格雷钠治疗的临床效果。方法180例脑血栓形成患者,采用随机数字表法分为对照组和试验组,每组90例。对照组患者单用依达拉奉治疗,试验组患者采用依达拉奉联合奥扎格雷钠治疗。对比两组治疗效果、不良事件发生情况、治疗后血脂[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)]水平及治疗前后神经功能缺损情况、血管紧张素Ⅱ(Ang-Ⅱ)、内皮素(ET)、脑脊液压力、舒张压。结果试验组治疗总有效率为94.44%,高于对照组的75.56%,差异具有统计学意义(P<0.05)。治疗后,试验组患者HDL-C(1.90±0.35)mmol/L高于对照组的(1.23±0.38)mmol/L,LDL-C(3.04±0.25)mmol/L、TG(1.23±0.39)mmol/L、TC(4.85±0.25)mmol/L低于对照组的(3.80±0.30)、(2.73±0.40)、(6.10±0.46)mmol/L,差异具有统计学意义(P<0.05)。治疗后,试验组NIHSS评分(3.20±1.12)分低于对照组的(7.50±1.62)分,差异具有统计学意义(P<0.05)。两组不良事件发生率对比差异无统计学意义(P>0.05)。治疗后,试验组Ang-Ⅱ(23.70±1.95)pg/ml、ET(53.15±3.15)pg/ml、脑脊液压力(1.45±0.25)kPa、舒张压(11.20±1.05)kPa均低于对照组的(28.40±2.15)pg/ml、(58.15±5.15)pg/ml、(1.65±0.38)kPa、(14.58±1.15)kPa,差异具有统计学意义(P<0.05)。结论在脑血栓形成治疗中采用奥扎格雷钠治疗效果突出,可有效改善患者血脂、神经功能、Ang-Ⅱ、ET、脑脊液压力、舒张压,安全性较高,建议推广应用。Objective To analyze the clinical effect of ozagrel sodium in the treatment of cerebral thrombosis.Methods A total of 180 patients with cerebral thrombosis were divided into control group and experimental group by random numerical table,with 90 cases in each group.Patients in the control group were treated with edaravone alone,and patients in the experimental group were treated with edaravone combined with ozagrel sodium.Both groups were compared in terms of therapeutic effect,occurrence of adverse events,blood lipids[high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)]after treatment and neurological deficits,angiotensinⅡ(Ang-Ⅱ),endothelin(ET),cerebrospinal fluid pressure,diastolic pressure before and after treatment.Results The total effective rate in the experimental group was 94.44%,which was higher than 75.56%in the control group,and the difference was statistically significant(P<0.05).After treatment,the HDL-C(1.90±0.35)mmol/L in the experimental group was higher than(1.23±0.38)mmol/L in the control group;the LDL-C(3.04±0.25)mmol/L,TG(1.23±0.39)mmol/L and TC(4.85±0.25)mmol/L in the experimental group were lower than(3.80±0.30),(2.73±0.40),and(6.10±0.46)mmol/L in the control group;the differences were all statistically significant(P<0.05).After treatment,the NIHSS score(3.20±1.12)points of the experimental group was lower than(7.50±1.62)points of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse events between the two groups(P>0.05).After treatment,the Ang-Ⅱ(23.70±1.95)pg/ml,ET(53.15±3.15)pg/ml,cerebrospinal fluid pressure(1.45±0.25)kPa,and diastolic blood pressure(11.20±1.05)kPa in the experimental group were lower than(28.40±2.15)pg/ml,(58.15±5.15)pg/ml,(1.65±0.38)kPa,and(14.58±1.15)kPa in the control group,and the differences were all statistically significant(P<0.05).Conclusion Ozagrel sodium is effective a

关 键 词：脑血栓形成 奥扎格雷钠 血脂 神经功能 脑脊液压力 

分 类 号：R743.32[医药卫生—神经病学与精神病学]