活源方联合四联疗法对幽门螺杆菌阳性脾胃气虚型慢性萎缩性胃炎患者血清胃蛋白酶原、肿瘤特异生长因子、胃癌单克隆抗体水平的影响  

Effects of Huoyuan Recipe combined with quadruple therapy on serum PG,TSGF and MG7⁃Ag levels in patients with Hp⁃positive chronic atrophic gastritis of spleen⁃stomach⁃qi deficiency type

作　　者：金战勇[1] 夏鹏飞[1] 屈建平 梁金[1] JIN Zhanyong;XIA Pengfei;QU Jianping;LIANG Jin(Department of Hepatobiliary Diseases,Hanyang Hospital District,Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430000,China;不详)

机构地区：[1]武汉市中医医院汉阳院区脾胃病肝胆病科,武汉430000 [2]湖北省中医医院花园山院区肝病中心,武汉430061

出　　处：《实用医学杂志》2022年第18期2357-2362,共6页The Journal of Practical Medicine

基　　金：武汉市医学科研项目(编号:WZ21C41)。

摘　　要：目的探究活源方联合四联疗法对幽门螺杆菌(Hp)阳性脾胃气虚型慢性萎缩性胃炎患者血清胃蛋白酶原(PG)、肿瘤特异生长因子(TSGF)、胃癌单克隆抗体(MG7⁃Ag)水平的影响。方法选取2020年10月至2021年9月于武汉市中医医院收治的Hp阳性脾胃气虚型慢性萎缩性胃炎患者96例,通过随机数字表法分为对照组、观察组各48例。对照组使用四联疗法+安慰剂治疗,观察组使用四联疗法+活源方治疗。评估两组中医症候评分,胃肠功能检测仪检测胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素⁃17(G⁃17)水平;酶联免疫吸附法检测肿瘤坏死因子⁃α(TNF⁃α)、白细胞介素⁃6(IL⁃6)、C反应蛋白(CRP)、肿瘤特异性生长因子(TSGF)、MG7⁃Ag水平,通过病理评分评定患者临床病理情况,记录Hp转阴情况,对比两组治疗效果。结果治疗后,观察组胃痛、胃胀、乏力评分、TSGF、MG7⁃Ag、TNF⁃α、IL⁃6、CRP水平、慢性炎症、炎症活动度、腺体萎缩、肠上皮化生评分水平均低于对照组(P<0.05)。治疗后,观察组PGⅠ、PGⅡ、G⁃17水平高于对照组(P<0.05)。观察组Hp转阴率、有效率均高于对照组(P<0.05),观察组不良反应发生率低于对照组(P>0.05)。结论Hp阳性脾胃气虚型慢性萎缩性胃炎患者使用活源方联合四联疗法治疗,中医证候评分下降,PGⅠ、PGⅡ、TSGF、MG7⁃Ag、G⁃17水平改善,炎症反应减轻,患者病理评分均显著改善,Hp根除率提升,治疗效果显著。Objective To explore the effect of Huoyuan Recipe combined with quadruple therapy on serum pepsinogen(PG),tumor⁃specific growth factor(TSGF)and gastric cancer monoclonal antibody(MG7⁃Ag)levels in patients with Hp⁃positive chronic atrophic gastritis with spleen⁃stomach qi deficiency type.Methods A total of 96 patients with Hp⁃positive chronic atrophic gastritis of spleen⁃stomach⁃qi deficiency type who were admitted to Wuhan hospital of traditional Chinese medicine from October 2020 to September 2021 were selected and divided into the control group and the observation group by random number table method,48 cases in each group.Blind experiments were performed on condition the patients knew nothing about their respective therapy.The control group was treated with quadruple therapy+placebo,and the observation group was treated with quadruple therapy+Huoyuan Recipe.The TCM symptom scores of the two groups were evaluated,and the gastrointestinal function detector was used to detect pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),and gastrin⁃17(G⁃17)level.Enzyme⁃linked immunosorbent assay was used to detect tumor necrosis factor⁃α(TNF⁃α),interleukin⁃6(IL⁃6),C⁃reactive protein(CRP),TSGF,MG7⁃Ag levels.The clinicopathological conditions of the patients were assessed by patho⁃logical scoring.The Hp conversion was recorded,and the therapeutic effects of the two groups were compared.Results After treatment,the scores of stomach pain,bloating,fatigue,TSGF,MG7⁃Ag,TNF⁃α,IL⁃6,CRP levels,chronic inflammation,inflammatory activity,gland atrophy,and intestinal metaplasia scores in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of PGⅠ,PGⅡand G⁃17 in the observation group were significantly higher than those in the control group(P<0.05).The negative rate and effective rate of Hp in the observation group were significantly higher than those in the control group(P<0.05),and the incidence of adverse reactions in the observation gr

关 键 词：活源方 四联疗法 慢性萎缩性胃炎 脾胃气虚型 幽门螺杆菌 炎症反应 

分 类 号：R573.32[医药卫生—消化系统]