多酚干扰细菌群体感应研究进展  

Research Progress on Polyphenol-based Quorum Sensing Interfering

作　　者：王满满 吴胜波[1,2] 吴昊 张鹏[1,2] 张育淼[1] 乔建军 财音青格乐[1,2] WANG Man-man;WU Sheng-bo;WU Hao;ZHANG Peng;ZHANG Yu-miao;QIAO Jian-jun;CAIYIN Qing-ge-le(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Key Laboratory of Systems Bioengineering of Ministry of Education,Tianjin University,Tianjin 300072,China;Zhejiang Shaoxing Research Institute of Tianjin University,Shaoxing 312300,China;Synthetic Biology Research Platform,Tianjin Collaborative Innovation Center of Chemical Science and Engineering,Tianjin 300072,China)

机构地区：[1]天津大学化工学院,天津300072 [2]天津大学系统生物工程教育部重点实验室,天津300072 [3]天津大学浙江绍兴研究院,绍兴312300 [4]天津化学化工协同创新中心合成生物学平台,天津300072

出　　处：《中国生物工程杂志》2022年第9期93-104,共12页China Biotechnology

基　　金：国家重点研发计划(2019YFA0905600、2020YFA0906800、2020YFA0907900);国家自然科学基金(32070073);中国创新研究群体基金(21621004)资助项目。

摘　　要：多酚化合物是人类日常饮食中一类典型的天然产物,具有干扰分子信号通路、影响肠道菌群组成和保护人体肠道健康的功能。针对不同微生物群体感应(quorum sensing,QS)系统,多酚能够干扰细菌生物膜的形成和微生物致病性。介绍多酚的类型、来源和含量,总结多酚对多种QS相关表型,如菌体运动性、黏附性、生物膜形成和毒力因子的释放等具有的干扰作用,以及一些常见多酚对典型病原体的干扰作用,提出基于多酚的QS干扰在未来疾病治疗中面临的主要挑战。Polyphenols, a typical class of natural products in our daily diet, have functions of interfering with molecular signaling pathways, affecting the composition of gut microbiota, and protecting human health. Biofilm formation and microbial pathogenicity can be interfered by various polyphenols targeting different microbial quorum sensing(QS) systems, which provides a theoretical basis for the clinical applications of polyphenols. However, the complexity of polyphenol-based interference involves multifarious compounds, various microorganisms and intricate microbial phenotypes. First, a brief summary of types, sources, and amounts of polyphenols is introduced, including flavonoids, phenolic acids, stilbene, lignans, and others based on the number of phenolic rings and structural elements. Then the polyphenol-based interference targeting diverse QS-relevant phenotypes is summarized, including microbial motility, microbial adhesion, biofilm formation, and the release of virulence factors. Furthermore, various interference effects of some common polyphenols on the typical pathogens are summarized to contribute to potential applications. Finally, some key challenges and general perspectives on polyphenol-based interference for various future therapeutic applications are identified.

关 键 词：耐药性 群体感应干扰 多酚化合物 生物膜 

分 类 号：Q93[生物学—微生物学]