低分子肝素联合生大黄治疗高脂血症性重症急性胰腺炎的研究  

Study on the Treatment of Hyperlipidemic Severe Acute Pancreatitis with Low Molecular Weight Heparin and Raw Rhubarb

作　　者：罗晓斌 吴林[2] 黄国梁[3] LUO Xiao-bin;WU Lin;HUANG Guo-liang(Shantou University Medical College,Shantou,Guangdong,515000;Department of Gastroenterology,Shantou Central Hospital,Shantou,Guangdong;Emergency Department of Jieyang People􀆳s Hospital,Jieyang,Guangdong)

机构地区：[1]汕头大学医学院,515000 [2]广东省汕头市中心医院消化内科 [3]广东省揭阳市人民医院急诊科

出　　处：《岭南急诊医学杂志》2022年第5期424-426,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨低分子肝素联合生大黄治疗高脂血症性重症急性胰腺炎(hyperlipidemic severe acute pancreatitis,HLSAP)的临床疗效及安全性。方法:将60例HLSAP患者随机分为观察组(30例)和对照组(30例)。观察组在常规治疗(如禁食、胃肠减压、生长抑素、血液净化、制酸、解痉止痛、肠内外营养、胰岛素控制血糖等)的基础上加用低分子肝素联合生大黄,对照组单一应用低分子肝素或者生大黄。比较两组患者的腹痛缓解时间、胃肠功能恢复时间、炎症指标(CRP、PCT)恢复到正常范围的时间,甘油三酯(Triacylglycerol,TG)下降至安全范围(<5.65 mmol/L)的时间、平均住院时间等。结果:观察组腹痛缓解时间、胃肠功能恢复时间、炎症指标(CRP、PCT)恢复到正常范围的时间均较对照组短(P<0.05)。观察组TG下降至安全范围(<5.65 mmol/L)的时间比对照组快(P<0.05),而平均住院时间较对照组短(P<0.05)。结论:低分子肝素联合生大黄治疗HLSAP可以有效缩短患者的腹痛缓解时间、胃肠功能恢复时间,抑制炎症反应,可以提高血中TG的清除速度,改善预后,值得临床推广应用。Objective:To investigate the clinical efficacy and safety of low molecular weight heparin combined with rhubarb in the treatment of hyperlipidemic severe acute pancreatitis(HLSAP). Methods:Sixty patients with HLSAP were domly divided into observation group(30 cases)and control group(30 cases). On the basis of routine treatment(such as fasting,gastrointestinal decompression,somatostatin,blood purification,antacid,spasmolysis and pain relief,enteral and parenteral nutrition,insulin control of blood sugar,etc.),the observation group added low molecular weight heparin and rhubarb,while the control group only used low molecular weight heparin or rhubarb. The time of abdominal pain relief,strointestinal function recovery,and inflammation indicators(CRP,PCT)returning to the normal range were compared between the two groups. The time of triglyceride(TG)dropping to the safe range(<5.65 mmol/L),and the average hospital stay were also compared. Results:The time of abdominal pain relief,gastrointestinal function recovery and inflammation index(CRP,PCT)recovery to normal in the observation group were shorter than those in the control group(P<0.05). The time of triglyceride falling to the safe range(<5.65 mmol/L)in the observation group was faster than that in the control group(P<0.05),and the average hospital stay was shorter than that in the control group(P<0.05). Conclusion:Low molecular weight heparin combined with raw rhubarb in the treatment of HLSAP can effectively shorten the time of abdominal pain relief,gastrointestinal function recovery,inhibit inflammatory reaction,improve the clearance rate of TG in blood,improve prognosis,and worthy of clinical application.

关 键 词：高脂血症性重症急性胰腺炎 低分子肝素 生大黄 

分 类 号：R576[医药卫生—消化系统]