多糖对炎症性疾病及肠道菌群调控作用的研究进展  

Advances in research of polysaccharides on inflammatory diseases and gut microbiota

作　　者：黄宇哲 吴前震 许腾龙 陈浩 张坤峰 陈洁琳 李大祥[3] 陈彦[1] HUANG Yu-zhe;WU Qian-zhen;XU Teng-fei;CHEN Hao;ZHANG Kun-feng;CHEN Jie-lin;Li Da-xiang;CHEN Yan(Key Laboratory of Ecological Engineering and Biotechnology of Anhui Province,School of Life Science,Anhui University,Hefei 230000,China;Nanjing Kang Zhi Chun Biological Technology Co.,Ltd,Nanjing 210000,China;State Key Laboratory of Tea Plant Biology and Utilization,School of Tea and Food Sciences and Technology,Anhui Agricultural University,Hefei 230036,China)

机构地区：[1]安徽大学生命科学学院,生态工程与生物技术安徽省重点实验室,安徽合肥230000 [2]南京康之春生物科技有限公司,江苏南京210000 [3]安徽农业大学茶与食品科学技术学院茶树生物学与利用国家重点实验室,安徽合肥230036

出　　处：《中国药理学通报》2022年第11期1601-1606,共6页Chinese Pharmacological Bulletin

基　　金：安徽省科技重大专项(No.202103a07020006);茶树生物学与资源利用国家重点实验室开放基金项目(No.SKLTOF20210118)。

摘　　要：肠道菌群是构建宿主营养代谢与健康的“桥梁”,维持着机体内环境稳定,在营养代谢、宿主免疫等生命活动中发挥着不可替代的作用。活性多糖广泛存在于天然产物中,是一类具有多种生理活性功能的生物大分子。现代科学研究表明,肠道菌群结构破坏会导致多种疾病的发生,多糖作为益生元可以通过调节肠道菌群及其生理环境来改善机体生理状态。该文主要综述了多糖作为肠道功能因子,可调节肠道菌群组成、修复肠道屏障、改善肠道微环境、促进分泌代谢产物及调节肠道免疫系统,且通过调节肠道菌群对结肠炎、结直肠癌和代谢综合征疾病的影响,以及与肠道微生态的构效关系。Gut microbiota is a bridge between the metabolism and health state of the host,which plays a very important role in maintaining homeostasis.Natural polysaccharides,widely existed in nature,are a kind of biological macromolecules with prebiotics effects,which can improve a degree of physiological status by selectively changing the gut microbiota structure and function,enhancing the content of short chain fatty acids(SCFAs)and decreasing the level of inflammatory cytokines.In addition,the majority of polysaccharides can be degraded by gut microbiota to enhance their bioavailability and to promote the health state of the host.In this paper we discuss the interaction among polysaccharides and gut microbiotanatural,degradation mechanism and review gut microbiota as a target in the treatment of metabolic diseases,so as to provide future prospects of natural polysaccharides as“prebiotics”functional factors in the field of biological medicine and health products.

关 键 词：多糖 肠道菌群 益生元 调节作用 降解机制 

分 类 号：R322.45[医药卫生—人体解剖和组织胚胎学] R343.9[医药卫生—基础医学] R516.1R574.62