具有生物活性的脱氢枞胺衍生物研究进展  

Research Progress of Biological Activities for Dehydroabietylamine Derivatives

作　　者：黄静玲 梁锦萍 周凤姬 何金芝 张振伟 陈清 林宁 HUANG Jing-ling;LIANG Jin-ping;ZHOU Feng-ji;HE Jin-zhi;ZHANG Zhen-wei;CHEN Qing;LIN Ning(Guangxi Zhuang Yao Medicine Center of Engineering and Technology,School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学药学院广西壮瑶药工程技术研究中心,广西南宁530001

出　　处：《化学试剂》2022年第11期1585-1597,共13页Chemical Reagents

基　　金：国家自然科学基金项目(21861009);广西自然科学基金项目(2021GXNSFDA075016,2018GXNSFAA281317,2020GXNSFAA297215);广西科技基地和人才专项项目(AD19245138);广西研究生教育创新计划项目(YCSW2020190)。

摘　　要：脱氢枞胺是松香的重要改性物质之一,也是歧化松香胺的主要成分,分子中具有稳定的手性三环菲结构和可修饰的胺基,可以与生物大分子进行手性识别,是一类重要的药性骨架。脱氢枞胺衍生物具有抗菌、抗病毒、抗癌等多种生物活性,可作为先导化合物用于新药发现。以脱氢枞胺衍生物展现出的生物活性为依据进行分类,介绍近年来具有生物活性的脱氢枞胺衍生物的研究进展,以期为该类化合物的后续研究提供参考。Dehydroabietylamine is one of the important modification substances of rosin, and also the main component of disproportionated rosin amine.It has a stable chiral tricyclic phenanthrene structure and modifiable amine group, which can be recognized with biological macromolecules.It is an important medicinal skeleton.Its derivatives have antibacterial, antiviral, and anticancer activities and can be used as lead compounds for new drug discovery.The biological activities of dehydroabietylamine derivatives were classified according to their different biological activities, and the research progress on the biological activities of dehydroabietylamine derivatives was introduced in order to provide a reference for the subsequent research of dehydroabietylamine derivatives.

关 键 词：脱氢枞胺 衍生物 先导化合物 生物活性 研究进展 

分 类 号：R914.5[医药卫生—药物化学]