无机纳米粒子在牙周病诊疗中的研究进展  

Research progress on the use of inorganic nanoparticles in the diagnosis and treatment of periodontal disease

作　　者：李伟光 吴亚菲[1] 郭淑娟[1] Li Weiguang;Wu Yafei;Guo Shujuan(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科,成都610041

出　　处：《国际口腔医学杂志》2022年第6期724-730,共7页International Journal of Stomatology

基　　金：四川省科技厅重点研发项目(2020YFS0175)。

摘　　要：无机纳米粒子(INPs)一般指结构单元的尺寸在1~100 nm的由非碳元素组成的新型纳米多功能材料。INPs具有生物相容性好、比表面积高、化学性质稳定、机械强度优良、成本低等诸多优势。INPs在抗菌、细胞标记、组织再生、药物靶向运输等方面研究广泛,在牙周疾病诊疗中的应用价值也受到了越来越多的关注。本文就INPs在牙周病的诊断和抗菌治疗,调节牙周局部免疫微环境,作为牙周药物载体以及促进牙周组织再生等多个方面的研究进展进行综述。Inorganic nanoparticles generally refer to new nano multifunctional materials that are composed of noncarbon elements with structural units ranging from 1 nm to 100 nm in size.They have many advantages,such as good biocompatibility,high specific surface areas,stable chemical properties,excellent mechanical strength,and low cost.Inorganic nanoparticles have been widely studied in the fields of antibacterial applications,cell labeling,tissue regeneration,and targeted drug transport.Their application value in the diagnosis and treatment of periodontal diseases has also attracted increasing attention.The progress in the use of inorganic nanoparticles in the diagnosis and treatment of periodontal disease,including their application in diagnosis,antibacterial treatment,regulating the local immune microenvironment of perio-dontal tissues,carrying periodontal drugs,and promoting periodontal tissue regeneration,is summarized.

关 键 词：无机纳米粒子 牙周病 生物活性材料 诊断 治疗 

分 类 号：R781.42[医药卫生—口腔医学]