Genome-wide methylation profiling reveals differentially methylated genes in blood DNA of small-cell lung cancer patients  

作　　者：Yanqi He Calvin Wei Zhifu Sun Julie M.Cunningham Liang Wang Zong Wei Ping Yang 

机构地区：[1]Division of Epidemiology,Department of Quantitative Health Sciences,Mayo Clinic,Scottsdale,AZ 85259,USA [2]Department of Respiratory and Critical Care Medicine,West China Hospital,Sichuan University,Chengdu 610041,China [3]Department of Physiology and Biomedical Engineering,Mayo Clinic,Scottsdale,AZ 85259,USA [4]School of Molecular Science,Arizona State University,Tempe,AZ 85281,USA [5]Division of Computational Biology,Department of Quantitative Health Sciences,Mayo Clinic,Rochester,MN 55905,USA [6]Genomic Shared Resource,Mayo Clinic Cancer Center,Rochester,MN 55905,USA [7]Program of Tumor Biology,Moffitt Cancer Center,Tampa,FL 33612,USA

出　　处：《Precision Clinical Medicine》2022年第3期192-194,共3页精准临床医学（英文）

基　　金：support from Mayo Clinic Foundation and U.S.National Cancer Institute(Grants No.R03-77118,R01-80127,and R01-84354)。

摘　　要：Dear Editor,Small-cell lung cancer(SCLC),one of the most-deadly malignant tumors,accounts for∼15%of all lung cancers.1,2 Although highly responsive to the standard chemoradiotherapy,the recurrence rate of SCLC is nearly unity,with median survival time ranging from 2–6 months.Almost all SCLC patients are inoperable,leading to the difficulty in obtaining adequate biopsy tissue for research.3 Consequently,there is an urgent need to find noninvasive biomarkers to predict the risk and provide early diagnosis of SCLC.We aimed to identify potential epigenomic markers for SCLC development in blood DNA and reveal differentially methylated genes through a multi-omics approach,from genome-wide DNA methylation profiling,followed by pathway enrichment analyses and target gene validation utilizing Gene Expression Omnibus(GEO)and Oncomine microarray databases,to TCGA PanCancer cohorts.It is known that virtually all patients with SCLC are victims of tobacco smoking,4 but it is unknown whether stopping smoking before SCLC diagnosis would influence the epigenetic biomarkers under investigation.We here report a study that identified aberrantly methylated genes between current and former smokers among SCLC patients,revealing a set of candidate biomarkers in peripheral blood DNA for better stratifying patients with high risk.

关 键 词：patients diagnosis cancer 

分 类 号：R734.2[医药卫生—肿瘤]