程序性细胞死亡方式在胃癌发生机制及诊疗中的研究进展  

Progresson of programmed cell death modes in pathogenesis,diagnosis and treatment of gastric cancer

作　　者：臧嘉益 崔明[1] 景蓉蓉[1] ZANG Jiayi;CUI Ming;JING Rongrong(Department of Laboratory Medicine,Affiliated Hospital of Nantong University,Nantong 226001;Medical School of Nantong University,Nantong University,Nantong 226001,China)

机构地区：[1]南通大学附属医院检验科,江苏南通226001 [2]南通大学医学院,江苏南通226001

出　　处：《南京医科大学学报（自然科学版）》2022年第10期1476-1481,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：中国博士后科学基金(2020M681689);江苏省博士后科研资助计划(2021K283B);南通科技项目(MS12021001);南通市卫生健康委员会课题(MA2021001)。

摘　　要：胃癌是世界上最常见的恶性肿瘤之一。由于缺乏早期诊断标志物以及对现有治疗方案耐药,胃癌患者预后相对较差。新型细胞死亡方式的研究有望为胃癌的诊疗提供新靶点。目前胃癌中新型细胞死亡方式包括铁死亡、焦亡、坏死性凋亡、自噬、溶酶体依赖性细胞死亡及NETosis,均属于程序性细胞死亡。本文介绍胃癌与这些新型细胞死亡方式间的相互关系及研究进展,以期为胃癌的诊断和靶向治疗提供理论依据和研究方向。Gastric cancer is one of the most common malignant tumor in the world.The prognosis is relatively poor due to the lack of early diagnostic markers and drug resistance to existing treatment options.The study of novel methods of cell death is expected to provide new targets for the diagnosis and treatment of gastric cancer.At present,novel cell death methods in gastric cancer include ferroptosis,pyroptosis,necroptosis,autophagy,lysosome-dependent cell death and NETosis,all of which belong to programmed cell death.In order to provide theoretical bases and research directions for the diagnosis and targeted therapy of gastric cancer,this article reviews the relationships between gastric cancer and cell death methods.

关 键 词：细胞死亡 胃癌 诊断 治疗 临床应用 

分 类 号：R735.2[医药卫生—肿瘤]