前列腺癌基因诊疗的研究进展  

Advances in the genetic diagnosis and treatment of prostate cancer

作　　者：李晋[1] 曹德宏[1] 魏强[1] 柳良仁[1] LI Jin;CAO De-hong;WEI Qiang;LIU Liang-ren(Department of Urology/Research Institute of Urology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西医院泌尿外科/泌尿外科研究所,四川成都610041

出　　处：《中华男科学杂志》2022年第8期715-721,共7页National Journal of Andrology

基　　金：国家自然科学基金(82000721);四川省科技厅基金(2020YJ0054)~~。

摘　　要：随着年龄增长前列腺癌(PCa)在男性中发病率逐渐上升,因而大众对PCa的防治更加重视。除外目前已广泛开展的前列腺特异抗原(PSA)检测与前列腺磁共振成像等检测方式,PCa相关基因筛查检测也随着二代基因测序等新技术的广泛开展在PCa患者中应用逐渐增多。不同类型的肿瘤相关基因对PCa的发生发展有不同的影响机制,同时各类基因在PCa的诊断、治疗以及预后管理等层面中价值各异。本文将PCa相关基因通路及重要基因的研究进展作综述。As the incidence of prostate cancer(PCa) increases with the aging of men, more and more attention is paid to the prevention and treatment of the pregnancy. In addition to widely used PSA test, MRI and other diagnostic strategies, PCa-related gene screening, with the development of such new technologies as second-generation gene sequencing, is more and more applied in the detection of PCa. Different types of tumor-related genes have different effects on the development and progression of PCa as well as different values in the diagnosis, treatment and prognosis of the malignancy. This review focuses on the advances in the studies of PCa-related critical genes and key gene pathways.

关 键 词：前列腺癌 基因 通路 

分 类 号：R737.25[医药卫生—肿瘤]