复杂多样的RNA修饰与癌症  

Complex and diverse RNA modifications and cancer

作　　者：曹潇月 石毓君[1] CAO Xiaoyue;SHI Yujun(Institute of Clinical Pathology,Key Laboratory of Transplant Engineering and Immunology,NHC,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)

机构地区：[1]四川大学华西医院临床病理研究所卫健委移植工程与移植免疫重点实验室,成都610041

出　　处：《中国普外基础与临床杂志》2022年第10期1270-1272,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：RNA在转录后可以被超过170种化学修饰标记,这些化学修饰被统称为RNA修饰,其打开了表观遗传学研究的新篇章,成为了近年来一大研究热点。RNA修饰通过调节RNA的命运,从转录组层面调控基因的表达,从而参与到多项生物学过程和疾病发生及发展。随着研究的深入,逐渐体现出RNA修饰的多样性和复杂性以及其不容被忽视的生理学意义和作为治疗靶点的潜力。RNA can be labeled by more than 170 chemical modifications after transcription,and these chemical modifications are collectively referred to as RNA modifications.It opened a new chapter of epigenetic research and became a major research hotspot in recent years.RNA modification regulates the expression of genes from the transcriptome level by regulating the fate of RNA,thus participating in many biological processes and disease occurrence and development.With the deepening of research,the diversity and complexity of RNA modification,as well as its physiological significance and potential as a therapeutic target,can not be ignored.

关 键 词：表观遗传学 RNA修饰 基因表达 转录组 

分 类 号：R730.2[医药卫生—肿瘤]