多发性内分泌肿瘤1型相关甲状旁腺功能亢进处理的研究进展  

Research progress in treatment of primary hyperparathyroidism in multiple endocrine neoplasm type 1

作　　者：徐天丰 郑洵 魏涛[1] XU Tianfeng;ZHENG Xun;WEI Tao(Department of Thyroid and Parathyroid Surgery,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)

机构地区：[1]四川大学华西医院甲状(旁)腺外科,成都610041

出　　处：《中国普外基础与临床杂志》2022年第10期1383-1389,共7页Chinese Journal of Bases and Clinics In General Surgery

基　　金：四川大学华西医院学科卓越发展1·3·5工程项目(项目编号:ZYJC21033)。

摘　　要：目的 总结多发性内分泌肿瘤1型(multiple endocrine tumors type 1,MEN1)相关原发性甲状旁腺功能亢进(primary hyperparathyroidism,PHPT)的处理方式。方法 对近年来国内外关于MEN1相关PHPT处理的相关文献进行归纳和总结。结果 MEN1相关PHPT的症状明显时,手术是其有效治疗手段,除常规的甲状旁腺全切除加部分自体移植术、甲状旁腺次全切除术外,切除范围较小的小于甲状旁腺次全切除、单腺体切除术也被证实有效。结论 结合MEN1相关PHPT患者的临床表现与甲状旁腺受累情况,个体化地选择适宜的手术时机、手术术式能够帮助MEN1相关PHPT患者获得理想的甲状旁腺功能状态,最大程度上保证MEN1相关PHPT患者的生活质量。Objective To summarize the research progress of the treatment of primary hyperparathyroidism(PHPT) in multiple endocrine neoplasm type 1(MEN1). Method The literature about the treatment of PHPT in MEN1in recent years was reviewed. Results When the symptoms of MEN1 related PHPT were obvious, surgery was an effective treatment. In addition to conventional total parathyroidectomy with autotransplantation and subtotal parathyroidectomy, less-than subtotal parathyroidectomy, and single gland excision had also been proved to be effective recently. Conclusions Combining the clinical manifestations with the actual involvement of the parathyroid of MEN1related PHPT patients, personalized selection of appropriate timing and methods of parathyroidectomy can help MEN1related PHPT patients obtain ideal parathyroid function and ensure the quality of life to the greatest extent.

关 键 词：多发性内分泌肿瘤1型 原发性甲状旁腺功能亢进 外科治疗 

分 类 号：R736[医药卫生—肿瘤] R582.1[医药卫生—临床医学]